Table 1.
Summary of study characteristics
| Publication | Model type | Perspective | Cycle length | Time horizon | DAS | PSA | Efficacy measure | Clinical measure |
|---|---|---|---|---|---|---|---|---|
| Beresniak 2011 [26] Spain | Decision Tree | TTP | 6 months | 2 years | No | Yes | Effect on DAS28-Score | DAS28-Score |
| Beresniak 2013 [30] Germany | Decision Tree | TTP | 6 months | 2 years | No | No | Effect on DAS28-Score | DAS28-Score |
| Chiou 2004 [31] USA | Decision Tree | TTP | 6 months | 1 year | Yes | No | ACR | ACR/VAS-Score |
| Choi 2000 [24] USA | Decision Tree | Societal | Not applicable | 6 months | Yes | No | ACR | - |
| Choi 2002 [16] USA | Decision Tree | Societal | Not applicable | 6 months | Yes | No | ACR | ACR Response/ No Response |
| Cimmino 2011 [27] Italy | Decision Tree | TTP | 6 months | 2 years | No | Yes | Effect on DAS28-Score | DAS28-Score |
| Kavanaugh 1996 [23] USA | Decision Tree | Not stated (Societal) | Not applicable | 6 months | Yes | No | - | Response, Partial Response, No Response |
| Moore 2004 [20] UK | Decision Tree | TTP | Not applicable | life-time | Yes | Yes | Reduction in Complications | Complications |
| Puolakka 2012 [28] Finnland | Decision Tree | TTP | 6 months | 2 years | No | Yes | Effect on DAS28-Score | DAS28-Score |
| Russell 2009 [25] Canada | Decision Tree | TTP | ?6 months | 2 years | No | Yes | Effect on DAS-Score | DAS-Score |
| Saraux 2010 [29] France | Decision Tree | TTP | 6 months | 2 years | No | Yes | Effect on DAS28-Score | DAS28-Score |
| Spiegel 2003 [21] USA | Decision Tree | TTP | Not applicable | life-time | Yes | Yes | Reduction in Complications | Complications |
| Zabinski 2001 [22] Canada | Decision Tree | TTP | Not applicable | life-time | Yes | No | Reduction in Complications | Complications |
| Bae 2003 [47] Korea | Markov Model | Not stated | 12 months | life-time | Yes | No | Reduction in Complications | Complications |
| Barbieri 2005 [45] UK | Markov Model | TTP | 6 months | life-time | Yes | No | Effect on HAQ-Score | HAQ-Score |
| Bessette 2009 [55] Canada | Markov Model | TTP | 1 month | 5 years | Yes | No | Reduction in Complications | Complications |
| Kobelt 1999 [33] Sweden | Markov Model | Not stated (Societal) | 12 months | 5 years | No | No | Effect on HAQ-Score | HAQ-Score |
| Kobelt 2002 [34] Sweden & UK | Markov Model | Societal | 12 months | 10 years | No | No | Effect on HAQ-Score | HAQ-Score |
| Kobelt 2003 [32] Sweden & UK | Markov Model | Not stated (Societal) | 12 months | 10 years | Yes | No | Effect on HAQ-Score | HAQ-Score |
| Kobelt 2005 [35] Sweden | Markov Model | not stated | not stated | 10 years | No | Yes | not stated | HAQ Score & VAS Score |
| Kobelt 2005a [36] Sweden | Markov Model | Societal | 12 months | 10 years | Yes | Yes | Effect on HAQ-Score | HAQ-Score |
| Kobelt 2011 [37] Sweden | Markov Model | Societal | 6 months | 10 years | No | Yes | Effect on HAQ- & DAS28 Score | HAQ-Score & DAS28-Score |
| Lekander 2010 [39] Sweden | Markov Model | Societal | ?12 months | 20 years | Yes | No | Effect on HAQ- & DAS28 Score | HAQ-Score & DAS28-Score |
| Lekander 2012 [38] Sweden | Markov Model | Societal | 12 months | 20 years | Yes | Yes | Effect on HAQ- & DAS28 Score | HAQ-Score & DAS28-Score |
| Lekander 2013 [40] Sweden | Markov Model | Not stated | 12 months | 10 years | No | Yes | Effect on HAQ- & DAS28 Score | HAQ-Score & DAS28-Score |
| Maetzel 2002 [49] Canada | Markov Model | TTP | 6 months | 5 years | No | Yes | - | ACR20 Response |
| Maetzel 2003 [48] Canada | Markov Model | TTP | 3 months | 5 years | Yes | No | Reduction in Complications | Complications |
| Marra 2007 [52] Canada | Markov Model | Societal | 1 week | 10 years | No | Yes | Effect on HAQ-Score | HAQ-Score |
| Nguyen 2012 [53] USA | Markov Model | TTP | 3 months | 5 years | Yes | Yes | - | ACR50 Response |
| Schädlich 2004 [55] Germany | Markov Model | TTP | 6 months | 3 years | Yes | No | - | ACR20 Response |
| Schipper 2011 [42] The Netherlands | Markov Model | Societal | 3 months | 5 years | Yes | Yes | Effect on DAS28-Score | DAS28-Score |
| Spalding 2006 [50] USA | Markov Model | Societal | 12 months | Life-time | Yes | No | Effect on HAQ-Score | HAQ-Score |
| Tanno 2006 [51] Japan | Markov Model | Not stated (Societal) | 6 months | Life-time | Yes | No | ACR | HAQ-Score |
| Welsing 2004 [41] The Netherlands | Markov Model | not stated | 3 months | 5 years | Yes | Yes | EULAR &ACR | DAS-Score |
| Wong 2002 [43] USA | Markov Model | Societal | 6 months | Life-time | Yes | No | Effect on HAQ-Score | HAQ-Score |
| Wu 2012 [56] China | Markov Model | TTP | 6 months | Life-time | Yes | Yes | - | ACR20/50/70 Response |
| Yun 2005 [47] Korea | Markov Model | Societal | 12 months | Life-time | Yes | No | Reduction in Complications | Complications |
| Bansback 2005 [57] Sweden | ISM | Not stated (TTP) | 6 months | Life-time | Yes | Yes | ACR | HAQ-Score |
| Brennan 2004 [15] UK | ISM | Societal | 6 months | Life-time | Yes | No | ACR | HAQ-Score |
| Brennan 2007 [58] UK | ISM | TTP | 6 months | Life-time | Yes | Yes | EULAR | HAQ Score |
| Diamantpoulus 2012 [68] Italy | ISM | TTP | 6 months | Life-time | Yes | Yes | - | ACR20/50/70 Response |
| Finckh 2009 [60] USA | ISM | Societal | 6 months | Life-time | Yes | Yes | Effect on HAQ-Score | HAQ-Score |
| Hallinen 2010 [63] Finnland | ISM | Societal | 6 months | 100 years | Yes | Yes | Effect on HAQ-Score | HAQ-Score |
| Kielhorn 2008 [61] UK | ISM | TTP | 6 months | Life-time | Yes | Yes | ACR | HAQ Score |
| Merkesdahl 2010 [62] Germany | ISM | TTP | 6 months | 100 years | Yes | Yes | ACR | HAQ-Score |
| Soini 2012 [64] Finnland | ISM | Societal | 6 months | Life-time | Yes | Yes | ACR | HAQ Score |
| Vera-Llonch 2008 [65] USA | ISM | TTP | 3 months | Life-time | Yes | Yes | Effect on HAQ-Score | HAQ-Score |
| Vera-Llonch 2008a [66] USA | ISM | Not stated | 3 months | Life-time | Yes | Yes | Effect on HAQ-Score | HAQ-Score |
| Wailoo 2008 [59] USA | ISM | TTP | 6 months | Life-time | Yes | Yes | ACR | HAQ-Score |
| Yuan 2010 [67] USA | ISM | TTP | 3 months | Life-time | Yes | Yes | Effect on HAQ-Score | HAQ-Score |
| Barton 2004 [70] UK | DES | Not stated | Not applicable | Life-time | No | No | Effect on HAQ-Score | HAQ-Score |
| Chen 2006 [71] UK | DES | TTP | Not applicable | Life-time | Yes | No | Effect on HAQ-Score | HAQ-Score |
| Clark 2004 [17] UK | DES | TTP | Not applicable | Not stated | Yes | No | Effect on HAQ-Score | HAQ-Score |
| Jobanputra 2002 [69] UK | DES | Not stated | Not applicable | Life-time | Yes | No | Effect on HAQ-Score | HAQ-Score |
| Kobelt 2009 [74] Sweden | DES | Societal | Not applicable | 10 years | Yes | Yes | Effect on HAQ- & DAS28 Score | HAQ-Score & DAS28-Score |
| Lindgren 2009 [73] Sweden | DES | Societal | Not applicable | Life-time | Yes | Yes | ACR | HAQ-Score & DAS28-Score |
| Malottki 2011 [72] UK | DES | Not stated (TTP) | Not applicable | Life-time | Yes | Yes | Effect on HAQ-Score | HAQ-Score |