Table 2.
Agents used in the model overall and differentiated by model type
| Abbreviation | Full name | Overall | Decision trees | Markov models | ISM | DES |
|---|---|---|---|---|---|---|
| ABA | Abatacept | 13 | 12 | 0 | 1 | 0 |
| ABA/MTX | Abatacept + Methotrexate | 11 | 0 | 0 | 10 | 1 |
| ADA | Adalimumab | 29 | 20 | 3 | 2 | 4 |
| ADA/MTX | Adalimumab + Methotrexate | 20 | 1 | 2 | 13 | 4 |
| ANA | Anakinra | 1 | 1 | 0 | 0 | 0 |
| ANA/MTX | Anakinra + Methotrexte | 9 | 1 | 0 | 0 | 8 |
| AZA | Azathioprine | 48 | 0 | 8 | 0 | 40 |
| BSC | Best Supportive Care | 47 | 0 | 1 | 18 | 28 |
| BSC/MTX | Best Supportive Care + Methotrexate | 4 | 0 | 0 | 4 | 0 |
| BUC | Bucillamine | 2 | 0 | 2 | 0 | 0 |
| CEL | Celecoxib | 3 | 0 | 3 | 0 | 0 |
| CER/MTX | Certolizumab + Methotrexate | 1 | 0 | 1 | 0 | 0 |
| COR | Corticosteroid | 1 | 0 | 1 | 0 | 0 |
| COX-2 | selective COX-2 inhibitor | 2 | 0 | 2 | 0 | 0 |
| CYC | Ciclosporin | 60 | 0 | 9 | 11 | 40 |
| CYC/MTX | Ciclosporin + Methotrexate | 35 | 1 | 0 | 0 | 34 |
| DIC | Diclofenac | 1 | 0 | 1 | 0 | 0 |
| DMARD | any Disease-Modifying-Anti-Rheumatic-Drug | 11 | 3 | 3 | 5 | 0 |
| ETA | Etanercept | 48 | 26 | 7 | 3 | 12 |
| ETA/MTX | Etanercept + Methotrexate | 18 | 2 | 3 | 9 | 4 |
| ETO | Etoricoxib | 1 | 1 | 0 | 0 | 0 |
| GOL/MTX | Golimumab + Methotrexate | 1 | 0 | 1 | 0 | 0 |
| Gold | 66 | 1 | 17 | 8 | 40 | |
| HCQ | Hydroxychloroquine | 12 | 0 | 0 | 0 | 12 |
| HCQ/MTX | Hydroxychloroquine + Methotrexate | 20 | 1 | 8 | 0 | 11 |
| IBU | Ibuprofen | 1 | 0 | 1 | 0 | 0 |
| INF | Infliximab | 19 | 8 | 4 | 4 | 3 |
| INF/MTX | Infliximab + Methotrexate | 36 | 1 | 8 | 11 | 16 |
| LEF | Leflunomide | 66 | 1 | 16 | 9 | 40 |
| LEF/MTX | Leflunomide + Methotrexate | 1 | 0 | 1 | 0 | 0 |
| MTX | Methotrexate | 115 | 10 | 41 | 30 | 34 |
| NAP | Naproxen | 2 | 1 | 1 | 0 | 0 |
| NSAID | (nonselective) nonsteroidal anti-inflammatory drugs | 5 | 1 | 4 | 0 | 0 |
| NSAID/H2RA | NSAID + H2 receptor antagonist | 1 | 1 | 0 | 0 | 0 |
| NSAID/MIS | NSAID + Misoprostol | 2 | 1 | 1 | 0 | 0 |
| NSAID/PPI | NSAID + proton pump inhibitor | 3 | 1 | 2 | 0 | 0 |
| PEN | Penicillamine | 22 | 0 | 0 | 0 | 22 |
| PRD/MTX | Prednisone/Prednisolone | 0 | 0 | 0 | 0 | 0 |
| ROF | Rofecoxib | 1 | 0 | 1 | 0 | 0 |
| RTX | Rituximab | 14 | 7 | 6 | 0 | 1 |
| RTX/MTX | Rituximab + Methotrexate | 21 | 0 | 0 | 20 | 1 |
| SUL | Sulfasalazine | 48 | 2 | 10 | 2 | 34 |
| SUL/HCQ/MTX | Sulfasalazine + Hydroxychloroquine + Methotrexate | 14 | 1 | 2 | 0 | 11 |
| SUL/MTX | Sulfasalazine + Hydroxychloroquine | 20 | 0 | 4 | 0 | 16 |
| TNF | TNF-inhibitor | 14 | 1 | 9 | 2 | 2 |
| TOC/MTX | Tocilizumab + Methotrexate | 3 | 0 | 0 | 3 | 0 |
| OVERALL | 872 | 106 | 183 | 165 | 418 |