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Inhibition of proliferation by LDM, MMC, ADM and the LDM constituents LDC and LDP in hepatoma cells (mean±SD)
| Drugs |
IC50 (nmol/L) |
|
| BEL-7402 | SMMC-7721 | |
| LDM | 0.003 ± 0.0006 | 0.064 ± 0.013 |
| MMC | 152.0 ± 27.3 | 1 136.6 ± 72.2 |
| ADM | 51.7 ± 6.5 | 378.0 ± 39.6 |
| LDC | 0.0032 ± 0.0005 | 0.0597 ± 0.0064 |
| LDP | 2 896.0 ± 345.5 | 1 896.0 ± 354.0 |
LDM: lidamycin; LDC: LDM enediyne chromophore; LDP: LDM apoprotein; ADM: adriamycin, MMC: mitomycin C.
