Table 6.
Healing by grade at 4, 8, 12 wk comparing PPIs with H2RAs (PP rate)
|
4 wk |
8 wk |
12 wk |
|||||||||
| I | II | III | IV | I | II | III | IV | I | II | ||
| Number of arms | 2 | 4 | 3 | 2 | 5 | 3 | 1 | ||||
| sd PPIs | Pooled data | 53/60 | 128/162 | 20/54 | 23/23 | 166/178 | 28/47 | 2/3 | |||
| Pooled rate (%) | 88.3 | 79.0 | 37.0 | 100.0 | 93.3 | 59.6 | 66.7 | ||||
| sd H2RAs | Pooled data | 27/54 | 65/172 | 2/41 | 16/25 | 101/182 | 6/34 | 0/2 | |||
| Pooled rate (%) | 50.0 | 37.8 | 4.9 | 64.0 | 55.5 | 17.6 | 0 | ||||
| Summary RR | 1.760 | 2.037 | 5.588 | 1.502 | 1.648 | 2.766 | 2.525 | ||||
| 95%CI | 1.329-2.332 | 1.631-2.545 | 1.701-18.363 | 1.107-2.038 | 1.440-1.885 | 1.284-5.916 | 1.046-6.093 | ||||
| No. of arms | 2 | 4 | 2 | 2 | 4 | 2 | 1 | 1 | |||
| hd PPIs | Pooled data | 40/46 | 88/123 | 21/30 | 46/46 | 104/120 | 24/30 | 29/29 | 42/46 | ||
| Pooled rate (%) | 87.0 | 71.5 | 70.0 | 100.0 | 86.7 | 80.0 | 100.0 | 91.3 | |||
| sd H2RAs | Pooled data | 26/50 | 49/126 | 3/28 | 37/49 | 62/121 | 6/28 | 28/32 | 19/35 | ||
| Pooled rate (%) | 52.0 | 38.9 | 10.7 | 75.5 | 51.2 | 21.4 | 87.5 | 54.3 | |||
| Summary RR | 1.665 | 1.835 | 6.110 | 1.300 | 1.689 | 3.626 | 1.111 | 1.676 | |||
| 95%CI | 1.248-2.222 | 1.436-2.345 | 2.138-17.459 | 1.102-1.534 | 1.400-2.036 | 1.772-7.418 | 0.957-1.291 | 1.222-2.298 | |||
| Number of arms | 2 | 1 | 1 | 2 | 1 | 1 | |||||
| ld PPIs | Pooled data | 144/175 | 34/42 | 9/28 | 162/175 | 42/44 | 15/28 | ||||
| Pooled rate (%) | 82.3 | 81.0 | 32.1 | 92.6 | 95.5 | 53.6 | |||||
| sd H2RAs | Pooled data | 104/175 | 15/50 | 1/22 | 132/175 | 27/49 | 2/21 | ||||
| Pooled rate (%) | 59.4 | 30.0 | 4.5 | 75.4 | 55.1 | 9.5 | |||||
| Summary RR | 1.384 | 2.698 | 7.071 | 1.227 | 1.732 | 5.625 | |||||
| 95%CI | 1.202-1.592 | 1.724-4.224 | 0.967-51.707 | 1.116-1.349 | 1.335-2.249 | 1.440-21.980 | |||||
| Refractory esophagitis | |||||||||||
| Number of arms | 1 | 1 | 2 | 1 | 2 | ||||||
| sd PPIs | Pooled data | 62/77 | 11/22 | 105/116 | 13/15 | 18/29 | |||||
| Pooled rate (%) | 80.5 | 50.0 | 90.5 | 86.7 | 62.1 | ||||||
| sd H2RAs | Pooled data | 20/40 | 1/11 | 26/61 | 2/8 | 0/14 | |||||
| Pooled rate (%) | 50.0 | 9.1 | 42.6 | 25.0 | 0 | ||||||
| Summary RR | 1.606 | 5.500 | 2.117 | 3.229 | 35.881 | ||||||
| 95%CI | 1.158-2.228 | 0.835-25.337 | 1.575-2.845 | 1.034-10.091 | 0.728-1767.6 | ||||||
sd: standard dose; ld: low dose.