Table 3.
KEGG signaling pathways associated with transcriptome expression differences between the cyclic tensile strain and no treatment.
| Term | Count | % | P value | Genes |
|---|---|---|---|---|
| rno03030: DNA replication | 21 | 2.341137124 | 1.00E − 17 | LIG1, POLE, MCM2, POLA2, MCM3, LOC317415, RNASEH2B, MCM4, MCM5, MCM6, RPA3, PRIM1, RFC5, RPA2, MCM7, RFC4, RFC2, POLE3, POLD2, PRIM2, PCNA, FEN1 |
|
| ||||
| rno04110: cell cycle | 34 | 3.790412486 | 9.83E − 16 | E2F1, E2F5, DBF4, TTK, CHEK1, CHEK2, CCNE2, CCNE1, CDKN2A, MCM7, BUB1, MYC, CCNA2, BUB3, CDC6, RBL1, ESPL1, CDC20, CDK6, MCM2, CDC25C, MCM3, LOC317415, MCM4, MCM5, ATM, SMC3, MCM6, CCNB1, CCND1, MAD2L1, CCNB2, PLK1, PCNA, BUB1B |
|
| ||||
| rno03050: proteasome | 18 | 2.006688963 | 1.27E − 10 | PSMB10, PSMB4, PSMB7, PSMC6, PSMD14, PSMB6, PSMC5, PSMA6, PSMC4, PSMB1, PSMA5, PSME2, PSMA4, PSMB3, PSMC1, PSMA3, POMP, PSMD6 |
|
| ||||
| rno00240: pyrimidine metabolism | 20 | 2.229654404 | 1.06E − 07 | POLR3G, POLR1E, CTPS, POLE, POLR1A, POLR1C, CAD, POLA2, POLR3D, PRIM1, TYMS, UMPS, NME2, POLE3, NT5C3, RRM2, POLD2, PRIM2, UCK2, DUT |
|
| ||||
| rno03430: mismatch repair | 10 | 1.114827202 | 5.35E − 07 | EXO1, RFC5, RPA2, RFC4, RFC2, MSH2, LIG1, POLD2, PCNA, RPA3 |
|
| ||||
| rno04115: p53 signaling pathway | 15 | 1.672240803 | 3.77E − 06 | BID, STEAP3, CDK6, CHEK1, CHEK2, ATM, GTSE1, CCNE2, CCNB1, CCNE1, CCND1, CASP3, CDKN2A, CCNB2, RRM2 |
|
| ||||
| rno03420: nucleotide excision repair | 11 | 1.226309922 | 4.08E − 05 | RFC5, RPA2, RFC4, POLE3, RFC2, LIG1, POLE, POLD2, PCNA, ERCC1, RPA3 |
|
| ||||
| rno00230: purine metabolism | 21 | 2.341137124 | 8.38E − 05 | POLR3G, POLR1E, NUDT5, POLE, POLR1A, POLR1C, POLA2, PPAT, GART, POLR3D, PRIM1, NME2, POLE3, ATIC, NT5C3, RRM2, ADK, POLD2, PRIM2, PRPS2, PRPS1 |
|
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| rno00670: one carbon pool by folate | 6 | 0.668896321 | 6.33E − 04 | MTHFD1, MTHFS, TYMS, DHFR, ATIC, GART |
|
| ||||
| rno03440: homologous recombination | 7 | 0.780379041 | 0.001556012 | RPA2, NBN, POLD2, BRCA2, RAD54L, RPA3, RAD51 |
|
| ||||
| rno03410: base excision repair | 8 | 0.891861761 | 0.002577441 | POLE3, NEIL3, LIG1, POLE, POLD2, PCNA, APEX1, FEN1 |
|
| ||||
| rno04114: oocyte meiosis | 14 | 1.560758082 | 0.003751587 | PPP2R1B, SGOL1, ESPL1, CDC20, CDC25C, SMC3, CCNB1, CCNE2, CCNE1, MAD2L1, CCNB2, PLK1, BUB1, FBXO5 |
|
| ||||
| rno00270: cysteine and methionine metabolism | 7 | 0.780379041 | 0.00748193 | GOT1, AHCY, DNMT1, AHCYL2, AMD1, APIP, SMS |
|
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| rno05322: systemic lupus erythematosus | 11 | 1.226309922 | 0.014926373 | HIST1H2BA, HIST1H2BB, HIST1H2BH, SSB, LOC682330, LOC680498, HIST1H2BM, HIST1H4B, HIST2H2AC, HIST1H2AI, HIST3H2A, H2AFX, HIST1H2AO |
|
| ||||
| rno03040: spliceosome | 13 | 1.449275362 | 0.018817601 | PRPF31, PPIL1, EFTUD2, MAGOH, SNRPB2, CWC15, SNRPD2, SF3B2, PRPF19, PLRG1, THOC4, LSM3, SNRPF |
|
| ||||
| rno00480: glutathione metabolism | 7 | 0.780379041 | 0.039033496 | LAP3, ODC1, GSTA2, GSTA4, RRM2, SMS, GCLM |
|
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| rno03020: RNA polymerase | 5 | 0.557413601 | 0.039888482 | POLR3G, POLR1E, POLR1A, POLR1C, POLR3D |
|
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| rno04512: ECM-receptor interaction | 16 | 2.285714286 | 7.51E − 07 | IBSP, COL4A2, ITGA1, ITGA11, LAMA2, LAMA4, LAMB2, LAMA5, ITGB8, ITGA7, TNN, AGRN, LAMC1, COL11A1, THBS2, THBS4 |
|
| ||||
| rno04510: focal adhesion | 24 | 3.428571429 | 3.96E − 06 | IBSP, COL4A2, VAV3, ITGA11, ITGA1, IGF1, HGF, MYL9, LAMA2, LAMA4, LAMB2, LAMA5, ITGB8, ITGA7, PDGFRA, PDGFRB, TNN, LAMC1, EGF, COL11A1, FIGF, THBS2, SHC4, THBS4 |
|
| ||||
| rno05414: dilated cardiomyopathy | 11 | 1.571428571 | 0.003630871 | LAMA2, ADCY4, ITGB8, ITGA7, ADCY6, ITGA11, ITGA1, IGF1, CACNB3, CACNA1C, SGCB |
|
| ||||
| rno04270: vascular smooth muscle contraction | 12 | 1.714285714 | 0.00645965 | RAMP3, ADCY4, AGTR1A, ADORA2A, PPP1R12B, ADCY6, AVPR1A, NPR2, PRKG1, CACNA1C, PRKCE, MYL9 |
|
| ||||
| rno00230: purine metabolism | 14 | 2 | 0.010450898 | ADCY4, ENPP3, ADCY6, PDE10A, PDE3A, NPR2, PDE4D, AMPD3, POLD4, PDE7B, PDE4B, ENTPD4, ENTPD1, ENTPD2 |
|
| ||||
| rno05410: hypertrophic cardiomyopathy (HCM) | 9 | 1.285714286 | 0.02148213 | LAMA2, ITGB8, ITGA7, ITGA11, ITGA1, IGF1, CACNB3, CACNA1C, SGCB |
|
| ||||
| rno05412: arrhythmogenic right ventricular cardiomyopathy (ARVC) | 8 | 1.142857143 | 0.031599478 | LAMA2, ITGB8, ITGA7, ITGA11, ITGA1, CACNB3, CACNA1C, SGCB |
|
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| rno04614: renin-angiotensin system | 4 | 0.571428571 | 0.046740741 | AGTR1A, MME, ANPEP, ENPEP |