Fig. 6.

Inhibition of AKT activation promotes apoptosis and inhibits the metastasis of PCa cells induced by baicalein. a, b Expression of p-AKT, AKT, Bax, and Bcl-2 in DU145 and PC-3 cells after treatment with baicalein and/or LY294002. After treatment with LY294002A, DU145 and PC-3 cells were incubated in the absence or presence of baicalein (40 μM) for 48 h. The cell viability was measured by MTT assay (c, d), and the cell invasion was measured by a Transwell assay (e, f). The results are presented as the means ± SD of three independent experiments. *P < 0.05; **P < 0.01, compared with the control cells. ^# P < 0.05 or ^## P < 0.01, compared with the cells treated with baicalein