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. 2015 Jul 15;5:157. doi: 10.3389/fonc.2015.00157

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Copyright © 2015 Mauro, Naimo, Ricchio, Panno and Andò.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cross-talk between adiponectin and IGF-IR in breast cancer: overview of mechanisms. (A) Schematic structure of adiponectin monomer with different domains and proteolytic cleavage site indicated. fAd and gAd indicate full length and globular adiponectin, respectively. (B) In ERα-positive breast cancer cells, adiponectin, produced by adipocytes, binds to AdipoR1, and establishes cross-talk with membrane ERα and with IGF-IR. The enhanced phosphorylation of MAPK may allow the activation of IGF-IR, IRS-1, and ERα, which contribute to breast tumor growth and progression.