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Brain microdialysis. A microdialysis probe is surgically implanted into a specific brain region of interest. Aβ and other solutes from the brain ISF freely enter the semipermeable membrane of the microdialysis probe. Fractions of microdialysates obtained over a period of time are then used to quantify Aβ levels reflecting steady-state levels and/or clearance of Aβ from the brain after inhibition of Aβ production.
