Table 2. Significant selection regions that harbor candidate genes for stature identified by composite selection signals in all analyses of European and African cohorts.
Region | BTA | Location (Mb) | Top 0.1 (1)% SNPs | Candidate Genes | Candidate Population | Source of Discovery (References) |
---|---|---|---|---|---|---|
1 | 3 | 9.35–10.06 | 1 (15) | DUSP23 | European large | Human (Lanktree et al. 2011) |
2 | 3 | 24.00–24.83 | 1 (9) | SPAG17 | African large | Human (Weedon et al. 2008; Kim et al. 2010) |
3 | 3 | 50.62–56.96 | 5 (47) | PKN2 | European small | Human (Lanktree et al. 2011) |
4 | 3 | 105.09–106.96 | 11 (30) | SCMH1 | African large | Human (Weedon et al. 2008) |
5 | 5 | 26.88–27.50 | 4 (8) | ATP5G2, ATF7 | European small | Human (Okada et al. 2010) |
6 | 6 | 38.29–39.75 | 10 (29) | NCAPG, LCORL | European large | Human, cattle, and horse (Gudbjartsson et al. 2008; Weedon et al. 2008; Soranzo et al. 2009; Lango Allen et al. 2010; Okada et al. 2010; Pryce et al. 2011) |
7 | 7 | 43.42–46.75 | 20 (36) | CAMLG, DDX46, TXNDC15, CATSPER3, PITX1a | European small | Human (Gudbjartsson et al. 2008) |
8 | 8 | 83.05–83.89 | 3 (13) | FBP2, PTCH1 | African small | Human and cattle (Weedon et al. 2008; Kim et al. 2010; Lanktree et al. 2011; Pryce et al. 2011) |
9 | 10 | 59.38–59.97 | 1 (12) | CYP19A1 | African small | Human (Okada et al. 2010; Lanktree et al. 2011) |
10 | 14 | 24.79–28.25 | 21 (66) | TGS1, LYN, RPS20, MOS, PLAG1, CHCHD7, SDR16C5, RDHE2, PENK | European large | Human, cattle, and horse (Gudbjartsson et al. 2008; Soranzo et al. 2009; Okada et al. 2010; Lango Allen et al. 2010; Lettre et al. 2008; Pryce et al. 2011) |
11 | 19 | 27.64–28.63 | 6 (16) | POLR2A | European large | Human (Lanktree et al. 2011) |
12 | 19 | 48.01–49.01 | 1 (14) | WDR68, MAP3K3, LYK5, GH1 | African small | Human (Gudbjartsson et al. 2008; Soranzo et al. 2009; Lanktree et al. 2011) |
Candidate gene locus is localized slightly over 1 Mb in the surrounding of a significant region.