Table 1. Aspergillus fumigatus phosphatase gene families.

Familya	Subfamilyb	Class/Domainc	A. fumigatus ID Genes	A. fumigatus Proteins	Effect of the Deletion on A. fumigatus	A. nidulans Genes	S. cerevisiae Protein
S/T	PPP	PP2Ac	Afu5g12010	PphA	Viable	AN0103	Pph3p
S/T	PPP	PP2Ac	Afu5g11370	PpgA	NDd	AN0164	Ppg1p
S/T	PPP	PP2Ac	Afu1g04950	GlcA	Lethal	AN0410 bimG	Glc7p
S/T	PPP	PP2Ac	Afu6g11470	SitA	Viable	AN0504 sitA	Sit4P
S/T	PPP	PP2Ac	Afu2g03950	PpzA	Viable	AN3793	Ppz1p
S/T	PPP	PP2Ac	Afu6g10830	PphB	Lethal	AN6391 pphA	Pph21p
S/T	PPP	PP2Ac	Afu5g06700	PptA	Viable	AN10281	Ppt1p
S/T	PPP	PP2Bc	Afu5g09360	CalA/CnaA	Viable	AN8820 cnaA	Cmp2p
S/T	PPM	PP2Cc	Afu1g15800	PtcA	Viable	AN0914	Ptc6p
S/T	PPM	PP2Cc	Afu1g09280	PtcB	Viable	AN1358	Ptc2p
S/T	PPM	PP2Cc	Afu8g04580	PpmA	Viable	AN1467	−/−
S/T	PPM	PP2Cc	Afu5g13740,	PtcD,	Both viable	AN2472	Ptc2p
			Afu2g03890	PtcE
S/T	PPM	PP2Cc	Afu1g06860	PtcF	Viable	AN5722	Ptc5p
S/T	PPM	PP2Cc	Afu5g13340	PtcG	Viable	AN6892	Ptc1p
S/T	PPM	PP2Cc	Afu4g00720	PtcH	Viable	AN2472	Ptc1p
S/T	Asp-based	HAD	Afu1g09460	NemA	Viable	AN1343	Nem1p
S/T	Asp-based	HAD	Afu3g11410	FcpA	Lethal	AN2902	Fcp1p
S/T	Asp-based	HAD	Afu1g04790	PsrA	Viable	AN10077	Psr1p
PTP	Dual-specificity	DSPc	Afu5g11690	PpsA	Viable	AN0129	−/−
PTP	Dual-specificity	DSPc	Afu4g07080	DspC	Lethal	AN4419	−/−
PTP	Dual-specificity	DSPc	Afu2g02760	DspD	Viable	AN4544	−/−
PTP	Dual-specificity	DSPc	Afu3g12250	CdcA	Viable	AN5057	Cdc14p
PTP	Dual-specificity	DSPc	Afu1g13040	DspA	Viable	AN10138	−/−
PTP	Dual-specificity	DSPc	Afu1g03540	DspB	Viable	AN4057	−/−
PTP	Classical	PTPc	Afu3g10970	PtpB	Viable	AN4896	Ptp1p
PTP	Classical	PTPc	Afu4g04710	PypA	Viable	AN6982	Ptp2p
PTP	LMW-PTP	LMWPc	Afu2g01880	LtpA	Viable	AN10570	Ltp1p/Yvh1p
SSU72	SSU72	SSU72	Afu2g03760	SsuA	NDd	AN3810	Ssu72p
PTP	CDC-25 type	CDC25	Afu6g08200	NimT	NDd	AN3941 nimT	−/−
PTP	—	Y-fosfatase	Afu4g07000	YphA	Viable	AN4426	−/−
PTP	—	Y-fosfatase 3	Afu6g06650	PtyA	Viable	AN5767	Ptc7p

^aFamily abbreviations: S/T, serine/threonine; PTP, protein tyrosine phosphatase.

^bSubfamily abbreviations: PPP, phosphoprotein phosphatase; PPM, Mg₂₊ or Mn₂₊-dependent protein phosphatase; Asp-based, aspartate-based phosphatase; LMW-PTP, low-molecular-weight protein tyrosine phosphatase; CDC25 type, cell division cycle 25 type; SSU72, C-terminal domain RNA Pol II phosphatase.

^cClass/domain abbreviations: PP2Ac, protein phosphatase 2 A catalytic subunit; PP2Bc, protein phosphatase 2B catalytic subunit; PP2Cc, protein phosphatase 2C catalytic subunit; HAD, haloacid dehalogenase; PTPc, protein tyrosine phosphatase catalytic subunit; DSPc, dual-specificity phosphatase catalytic subunit; LMWPc, low-molecular-weight phosphatase catalytic subunit; CDC25, cell division cycle; SSU72, C-terminal domain RNA polymerase II phosphatase; Y-phosphatase 3, tyrosine phosphatase 3.

^dNot determined.