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. 2015 Jul 15;5:12166. doi: 10.1038/srep12166

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(a,b) HTT IP-FCM in brain lysates from Hu97/18, Hu18/18, conditional Htt KO, and wildtype mice using (a) HDB4/MW1 or (b) MW1/BKP1. (c,d) HTT-IP-FCM median fluorescence intensity (MFI) using serial dilutions of recombinant HTT fusion protein with 15 or 65 Q in ACSF using (c) HDB4/MW1 or (d) MW1/BKP1. Dashed lines indicate the mean ± SEM of the no-protein controls, showing assay background. (e) HDB4/MW1 IP-FCM in 1:150,000 Hu97/18 or Hu18/18 brain lysate. Red arrow indicates positive signal. (f) HDB4/MW1 IP-FCM in CSF from premanifest (green) and manifest (red) HD gene positive individuals. Control CSF (blue) and no-CSF assay controls (black) are also shown.