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. 2015 Jul 15;5:12166. doi: 10.1038/srep12166

Figure 4. The brain is a major source of CSF muHTT protein.

Figure 4

(a,b) BACHD and BACHDXB striatal and cortical tissues were evaluated for HTT protein levels by immunoblot and quantified in an N of 4 animals per group. (c) CSF HTT IP-FCM from the same animals demonstrates a 66% reduction in IP-FCM signal when brain muHTT protein is absent. (d) Quantification in an N of 4 animals per group of relative muHTT protein in CSF of Hu97/18 mice 3 or 7 days following intrastriatal injection of PBS vehicle or QA neurotoxin.