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. 2015 Jul 15;5:12155. doi: 10.1038/srep12155

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(a) Absorption of BBR and dhBBR in the Caco-2 cell model; L: The P_{app (AP-BL)} of dhBBR in Caco-2 cells was 11.9-fold higher than that of BBR (***P < 0.001); R: The efflux ratio of dhBBR in Caco-2 cells was significantly lower than that of BBR (1.58 vs. 32.39, ***P < 0.001). (b) Concentration-time curve for BBR or dhBBR in plasma after dhBBR oral administration (200 mg/kg) to rats (n = 3). (c) Concentration-time curve of BBR in plasma after the oral administration of dhBBR (200 mg/kg) or BBR (200 mg/kg) (n = 3). (d) Concentration-time curve of BBR in pseudo germ-free rats (generated by the oral administration of antibiotics for 3 days, curve 1) or in conventional SD rats (with no antibiotics, curve 2) after the oral administration of BBR (200 mg/kg, n = 3).