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. 2015 Jul 15;5:12155. doi: 10.1038/srep12155

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(a) Fasting blood glucose (Glu), triglyceride (TG) and cholesterol (CHO) in conventional KK-Ay mice or pseudo germ-free KK-Ay mice (n = 6) treated with (or without) BBR for 14 days; U: plasma glucose; M: plasma triglyceride; L: plasma cholesterol. (b) Number of intestinal bacteria colonies (in log scale) on day 14 (n = 6). (c) Plasma concentration of BBR in KK-Ay mice treated or untreated with antibiotics; U: C_max of BBR on day 14; L: folds of C_max[BBR/(BBR+antibiotics)] on days 1, 3, 6, 10 and 14 post-BBR oral administration. *P < 0.05, **P < 0.01, ***P < 0.001.