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Distribution of Fatigue Impact severity (FIS) scores in patients with mitochondrial disease (MM), healthy control volunteers (control); p < 0.001 and chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) patients. FIS ≥ 40 indicates excessive symptomatic fatigue; FIS ≥ 80 indicates severe symptomatic fatigue experienced in the past one month.
