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Inhibitory effects of compounds 1 and 2 on 2-OST and 3-OST. 2-OST, or 3-OST, was incubated with different concentrations of compound 1 or 2 in an acidic buffer at 4°C for 1h to allow the cross-linking between the compound and proteins. The reactants were then subjected to the activity measurement following the methods described under “Supplementary Information”.
