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. 2015 Jul 16;12:42. doi: 10.1186/s12950-015-0088-x

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© Wang et al. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Hypothesized regulatory networks among Zfp36l1, Zfp36l2, Mkp-1, and p38 MAPK in RAW264.7 cells. Under resting conditions, Zfp36l1 and Zfp36l2 interact with Mkp-1 mRNA 3’UTR and destabilize it, and the cells are sensitive to stimuli such as LPS under low Mkp-1 expression. During early LPS stimulation for 15 min, Zfp36l1 and Zfp36l2 were phosphoprylated and resulted in the decrease of their mRNA destabilization function; so that Mkp-1 mRNA and protein were induced to inactivate LPS-stimulated p38. pppGm⁷: 7-methylguanosine cap. P: phosphate group