Table 3.
OR values for NSCLC subgroups according to clinical characteristics
| Outcome of interest | Studies | Patients | OR | 95%CI | P value | Model | H, I2, P value |
|---|---|---|---|---|---|---|---|
| Age (>60 vs. <60) | n = 6 | 1531 | 1.08 | 0.85-1.37 | 0.553 | Fixed | 5.37,6.9 %,0.37 |
| Gender (Male vs. Female) | n = 11 | 2696 | 1.89 | 1.53-2.33 | 0.000 | Fixed | 10.52,5.0 %,0.40 |
| Asian | n = 8 | 1933 | 2.18 | 1.67-2.81 | 0.000 | Fixed | 5.97,0.0 %,0.54 |
| Non-Asian | n = 3 | 763 | 1.38 | 0.96-1.99 | 0.084 | Fixed | 0.97,0.0 %,0.61 |
|
Smoke habits
(Smoke vs. Non-smoke) |
n = 7 | 1785 | 2.20 | 1.72-2.82 | 0.000 | Fixed | 4.77,0.0 %,0.57 |
| Non-ADC vs. ADC | n = 15 | 3185 | 1.88 | 1.60-2.22 | 0.000 | Fixed | 17.13,18.3 %,0.25 |
| Asian | n = 10 | 2345 | 2.22 | 1.82-2.70 | 0.000 | Fixed | 3.81,0.0 %,0.92 |
| Non-Asian | n = 5 | 840 | 1.31 | 0.98-1.75 | 0.073 | Fixed | 4.74,15.6 %,0.32 |
| T 2-4 vs T 1 | n = 9 | 2156 | 1.46 | 1.13-1.88 | 0.004 | Fixed | 3.13,0.0 %,0.93 |
| Asian | n = 7 | 1938 | 1.47 | 1.12-1.94 | 0.006 | Fixed | 2.86,0.0 %,0.83 |
| Non-Asian | n = 2 | 218 | 1.37 | 0.71-2.65 | 0.349 | Fixed | 0.23,0.0 %,0.63 |
| N 1-3 vs N 0 | n = 11 | 2443 | 1.01 | 0.83-1.22 | 0.927 | Fixed | 10.73,6.8 %,0.38 |
| Differentiation (well vs. moderate/poor) | n = 9 | 2029 | 1.47 | 1.15-1.88 | 0.002 | Fixed | 6.04,0.0 %,0.64 |
| Asian | n = 7 | 1837 | 1.50 | 1.15-1.94 | 0.002 | Fixed | 5.14,0.0 %,0.53 |
| Non-Asian | n = 2 | 192 | 1.28 | 0.60-2.74 | 0.517 | Fixed | 0.81,0.0 %,0.37 |
Abbreviation: ADC adenocarcinoma, CI confidence interval, Fixed, Fixed, Inverse Variance model, H Heterogeneity, I2 I-squared, OR,odds Ratio