Table 1.
Reported impact of mood disorder risk genes on brain morphology in healthy subjects.
| Genes | Comparison | Amygdala |
ACC |
OFC |
Hippocampus |
||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Nst | Nsj | Ws (%) | Nst | Nsj | Ws (%) | Nst | Nsj | Ws (%) | Nst | Nsj | Ws (%) | ||
| SLC6A4 | S>L 1 | 37 | 4.5 | – | – | – | – | – | – | – | – | – | |
| S<L | 3 | 302 | 91.7 | 3 | 232 | 100.0 | 1 | 41 | n.a. | 1 | 77 | 27.8 | |
| L=S | 1 | 45 | 3.8 | – | – | – | – | – | – | 2 | 100 | 72.2 | |
| MAOA | L>H | – | – | – | – | – | – | 2 | 101+ | 78.6 | – | – | – |
| L<H | 1 | 97 | n.a. | 1 | 97 | 62.2 | – | – | – | – | – | – | |
| L=H | – | – | – | 1 | 59* | 37.8 | 1 | 55+ | 21.4 | – | – | – | |
| HTR2A | His>Tyr | – | – | – | – | – | – | – | – | – | 1 | 76 | n.a. |
| COMT | Met>Val | 3 | 203 | 100.0 | – | – | – | – | – | – | 4 | 353 | 94.9 |
| Met<Val | – | – | – | – | – | – | 1 | 53 | n.a. | – | – | – | |
| Met=Val | – | – | – | – | – | – | – | – | – | 1 | 76 | 5.1 | |
| BDNF | Met<Val | 1 | 87 | 2.0 | 1 | 42 | n.a. | – | – | – | 9 | 649 | 94.6 |
| Met=Val | 5 | 483 | 98.0 | – | – | – | – | – | – | 2 | 167 | 5.4 | |
| mtDNA | A>G | 1 | 118 | n.a. | – | – | – | – | – | – | – | – | – |
| DISC1 | Ser>Cys | – | – | – | 1 | 108 | n.a. | – | – | – | 1 | 71 | 34.0 |
| Ser<Cys | – | – | – | – | – | – | – | – | – | 1 | 157 | 11.8 | |
| Ser=Cys | – | – | – | – | – | – | – | – | – | 1 | 108 | 54.2 | |
| PER3 | 4/4>5/5 | 1 | 29 | n.a. | 1 | 29 | n.a | ||||||
| VEGF | T<C | – | – | – | – | – | – | – | – | – | 1 | 47 | n.a. |
| A<C | – | – | – | – | – | – | – | – | – | 1 | 47 | n.a. | |
Genotypes of genes can be found in the text of this article. Gene nomenclature corresponds to OMIM (Online Mendelian Inheritance in Man), corresponding RefSNP accession numbers are mentioned in the text. S or L of SLC6A4 comprises the biallelic or triallelic classification of 5-HTTLPR. ACC, anterior cingulate cortex; OFC, orbitofrontal cortex; Nst, number of studies; Nsj, number of subjects; Ws, support index weighted for number of studies and number of subjects (formula available in Supplementary data); n.a., not applicable;
*
, males only;
+
, females only.