Table 2.
Mean hedonic ratings of side effects with clozapine treatment grouped by deterioration and improvement (n = 56).
| Effects that deteriorated for 20% or more of patients |
Effects that improved for 20% or more or patients |
||||
|---|---|---|---|---|---|
| mean hedonic rating | % patients (n) | mean hedonic rating | % patients (n) | ||
| Nocturnal salivation | 1.72 | 84% (47) | Quality of life | 4.37 | 68% (38) |
| Weight gain | 1.81 | 57% (32) | Activity level | 4.35 | 36% (20) |
| Daytime salivation | 1.83 | 41% (23) | Alertness | 4.31 | 29% (16) |
| Constipation | 1.86 | 39% (22) | Social life | 4.24 | 52% (29) |
| Unusual movement | 2.00 | 21% (12) | Mood | 4.21 | 43% (24) |
| Energy | 2.14 | 38% (21) | Thinking | 4.19 | 46% (26) |
| Dry mouth | 2.15 | 23% (13) | Energy levels | 4.14 | 25% (14) |
| Appetite | 2.18 | 20% (11) | Sleep | 4.07 | 48% (27) |
| Itchiness | 2.27 | 20% (11) | |||
| Sleep | 2.27 | 20% (11) | |||
| Thirst | 2.40 | 27% (15) | |||
| Appetite | 2.87 | 41% (23) | |||
Note: Feelings rated on a 5-point scale: 1 = very unhappy about it; 2 = unhappy about it; 3 = don’t mind either way; 4 = happy about it; 5 = very happy about it.