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. Author manuscript; available in PMC: 2015 Jul 15.
Published in final edited form as: Eur Neuropsychopharmacol. 2014 Jul 3;24(9):1463–1474. doi: 10.1016/j.euroneuro.2014.06.013

Figure 1.

Figure 1

Heat maps displaying binding affinities (pKi values) (a) and adverse drug reaction (ADR) (%) profiles (b) for 39 psychotropic medications comprising different drug classes (SSRI, selective serotonin re-uptake inhibitor; SNRI, serotonin-norepinephrine re-uptake inhibitor; NDRI, norepinephrine-dopamine re-uptake inhibitor; NaSSA, noradrenergic and specific serotonergic anti-depressant; SARI, serotonin antagonist and re-uptake inhibitor; TeCA, tetracyclic antidepressant; TCA, tricyclic antidepressant; AAP, atypical antipsychotic; TAP, typical antipsychotic). Binding affinities (in pKi values) range from 5 (inactive, black) to 9.68 (highly active, white), whereas ADR frequencies (in %) range from 0% (no occurrence, black) to 67.9% (very frequent, white). Binding affinity profiles were extracted from the Psychoactive Drugs Screening Program (PDSP) database and side effect frequencies are based on clinical trial data extracted from the Cochrane Database of Systematic Reviews (CDSR).