Table 1.
Adverse and beneficial effects of antagonistic action at common drug targets of antidepressants and antipsychotics. Variable importance values are displayed (Figure S2) with values greater than one in the O-PLS analysis. (+) indicates that inhibition of the target is positively correlated to any specific adverse drug reaction (ADR) and possibly causal, whereas (−) stands for a negative correlation with the ADR putatively reflecting protective properties. (+ +) and (− −) denote variable importance values higher than 1.5.
| Drug. target | Diarrhea | Nausea | Hypotension | Dizziness | Headache | Insomnia | Sedation | Sleepiness | Increased sweating | Weight gain |
|---|---|---|---|---|---|---|---|---|---|---|
| 5-HTT | + | + | − | − − | − | + + | − | |||
| NET | + | |||||||||
| DAT | + | |||||||||
| 5-HT1A | − | + | ||||||||
| 5-HT1B | + | |||||||||
| 5-HT1D | ||||||||||
| 5-HT2A | − − | − | + + | + | + + | + | − | + + | ||
| 5-HT2C | − | + | + | − | + + | |||||
| 5-HT3 | + | |||||||||
| 5-HT6 | + | − | + + | |||||||
| 5-HT7 | − | − | + + | + | ||||||
| α 1 | − | + + | + + | + | + | + | + | |||
| α 2 | ||||||||||
| β 1 | ||||||||||
| M1 | + | − − | ||||||||
| M2 | + | − | ||||||||
| M3 | + | + + | ||||||||
| M4 | + | − | ||||||||
| M5 | + | + + | − | + | ||||||
| D1 | − | + | − | |||||||
| D2 | − − | − − | + + | − | + + | + | + | + | ||
| D3 | − − | − | + + | + + | + | |||||
| D4 | + | |||||||||
| H1 | − − | − − | − − | + + | + + | − − | + + |