. 2015 Jan 30;11(1):155–165. doi: 10.4161/15548627.2014.994346

Table 2.

Basic statistics of the Autophagy Regulatory Network

Data sources and layers	Identical nodes	Identical edges
Core autophagy proteins	38	238
ADB²⁰	31	114
ARN manual curation	20	26
Behrends et al.²¹	26	38
BioGRID⁴⁴	30	76
ELM-based prediction³⁸	16	64
HPRD⁴⁷	11	11
InnateDB⁴⁵	28	40
IntAct⁴⁶	34	136
Post-translational regulators	13,803	197,167
ADB	206	381
ARN manual curation	47	46
Behrends et al.	398	441
BioGRID	12,051	71,496
Domain-domain based prediction	166	1,138
ELM-based prediction	937	78,824
HPRD	7,290	29,617
InnateDB	2,816	6,125
IntAct	9,862	45,745
Transcriptional regulators	13,340	170,245
ABS⁴⁰	23	14
ARN manual curation	31	35
ENCODE⁴¹	2,209	9,217
HTRI²⁹	12,209	39,477
JASPAR¹⁵	12,813	119,873
ORegAnno⁴²	908	932
PAZAR⁴³	1,940	3,018
Post-transcriptional regulators	7,633	20,186
miR2Disease⁴⁸	171	124
miRDeathDB⁴⁹	126	108
miRecords⁵⁰	664	760
miRTarBase⁵¹	7,203	19,177
TarBase⁵²	1,798	2,584
Transcriptional regulation of miRNAs	646	6,911
ENCODE	195	590
PuTmiR 1.1⁵³	413	3,034
PuTmiR 2.0	288	3,095
TransmiR⁵⁴	291	542
Signaling pathways and interactions	1,199	3,287
SignaLink 2 manual curation⁵⁵	1,199	3,287
BioGRID	535	697
HPRD	481	611
InnateDB	9	51
IntAct	12	69

Data sources of each layer are listed with the corresponding number of nodes (i.e., proteins or miRNAs) and edges (i.e., protein-protein interactions, TF-gene, miRNA-mRNA, or TF-miRNA regulatory connections). The number of identical nodes shows both connecting component pairs (i.e., TFs and target genes as well). For each major layer we highlighted the total number of nodes and edges in ARN that is generally less than the sum of the components due to the overlap among the resources. Note that the highlighted numbers in each layer are higher than those in any of the sources.