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. 2014 Oct 30;10(11):1883–1894. doi: 10.4161/auto.32154

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Figure 6. — NAC treatment impairs physical performance and mitochondria function in atg7^f/f mice. (A) Mean maximal running distance after 1 (left) and 3(right) d of eccentric exercise with and without NAC treatment in atg7^f/f and atg7^−/− females (NAC-treated n = 6 atg7^f/f, n = 4 atg7^−/−). NAC treatment did not improve atg7^−/− but rather worsened atg7^f/f physical performance. (B) TMRM analysis of atg7^f/f females pre-exercise (top) and postexercise (bottom) after NAC treatment. Mitochondrial ability to maintain membrane potential is compromised by prolonged antioxidant treatment (n > 15 per condition).