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. 2014 Dec 18;10(11):2053–2074. doi: 10.4161/15548627.2014.973737

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© 2014 The Author(s). Published with license by Taylor & Francis

© Daniele De Stefano, Valeria R Villella, Speranza Esposito, Antonella Tosco, Angela Sepe, Fabiola De Gregorio, Laura Salvadori, Rosa Grassia, Carlo A Leone, Giuseppe De Rosa, Maria C Maiuri, Massimo Pettoello-Mantovani, Stefano Guido, Anna Bossi, Anna Zolin, Andrea Venerando, Lorenzo A Pinna, Anil Mehta, Gianni Bona, Guido Kroemer, Luigi Maiuri, and Valeria Raia

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 9. — Effects of treatment on respiratory inflammation in vivo in F508del-CFTR homozygous patients. (A and B) TNF and CXCL8 transcript levels in nasal brushing from all the enrolled CF patients before (wk 0) and after 4, 8 and 12 wk of treatment. (A) TNF, ##P = 0.026 and (B) CXCL8, ##P = 0.023 vs wk 0. (C and D) TNF and CXCL8 protein levels (pg/ml) in the sputum before treatment (wk 0) and after 4, 8 and 12 wk of treatment. (C) TNF, ##P = 0.0019, #P = 0.016 as compared to wk 0. (D) CXCL8, #P = 0.024 vs wk 0. (E) Correlation between absolute changes in TNF protein levels (pg/ml) in the sputum after 12 wk of treatment and in sweat chloride levels (mmol/L) after 4 wk of treatment. The Spearman r = 0.770, P = 0.009.