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. 2015 Jan 28;10(12):2297–2309. doi: 10.4161/15548627.2014.994359

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© 2014 The Author(s). Published with license by Taylor & Francis

© Natalie Spang, Anne Feldmann, Heike Huesmann, Fazilet Bekbulat, Verena Schmitt, Christof Hiebel, Ingrid Koziollek-Drechsler, Albrecht M Clement, Bernd Moosmann, Jennifer Jung, Christian Behrends, Ivan Dikic, Andreas Kern, and Christian Behl

This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.

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Figure 1. — RBG-1 affects proteostasis and autophagy. (A) Paralysis of rbg-1 and eV RNAi-treated CL2006 worms. 316 (eV) and 308 (rbg-1) worms were analyzed. Statistics are depicted as mean ± SD; *P < 0.05, **P < 0.01; n = 6; Oneway Anova. (B) Confocal images of thioflavine stained CL2006 worms and head regions of eV, rbg-1, and atg-7 RNAi-treated worms. Aggregates were counted in 42 (eV), 45 (rbg-1) and 34 (atg-7) head areas. Scale bars = 100 and 20 μm; ***P < 0.001, n = 4, t test. For estimation of background staining, we have employed N2 WT worms and confocal images are depicted in Fig. S2B. (C) Confocal images of seam cells of eV and rbg-1 RNAi-treated GFP-LGG-1 expressing worms and statistical analysis of the total number of autophagosomal structures in at least 20 different cells. Bec-1 RNAi served as control. Scale bars = 50 and 10 μm; statistics are depicted as mean ± SD; ***P < 0.001, n = 3, t test.