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Functional TP53 is required for sensitization of NSCLC cells to radiation. ((A)and B) tp53-null H1299 cells and ((C)and D) H1299 cells with TP53 induced by doxycycline (inset) were exposed to radiation (IR, 6 Gy) or EB 1089 in combination with radiation and cell viability was monitored for a period of 5 to 7 d. n = 3, mean ± SE. (Figs. 7B and 7D are expanded scales for IR and IR+EB 1089 *P < 0.05, #P < 0.001.).
