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. 2015 Jan 28;10(12):2346–2361. doi: 10.4161/15548627.2014.993283

Figure 8.

Figure 8.

Blocking autophagy reverses the sensitization in TP53-inducible H1299 cells. Cell viability studies indicate that inhibition of autophagy in H1299 parental tp53-null cells by using either. (A) chloroquine or genetic silencing of (C) ATG5 or (E) BECN1 did not cause any change in sensitivity of the cells. However in TP53-inducible H1299 cells blocking autophagy either by using (B)chloroquine or genetically silencing (*P < 0.05, #P < 0.001) (D) ATG5 (*P < 0.05, #P < 0.001) or (F) BECN1 (*P < 0.05, #P < 0.001) reversed the sensitization that was achieved with the combination treatment of EB 1089 and radiation. n = 3, mean ± SE.