Figure 11.

RPE degeneration leads to retinal degeneration. Loss of autophagy function in the RPE resulted in a secondary loss of photoreceptors. (A) The retinal thinning was due to reduction in the ONL as seen on cross section OCT imaging of 8-moold mice, and (B) the automated ONL thickness measurement shown as a heat map. (C) Manual measurement of the ONL thickness vs. total retinal thickness confirmed the automated measurements. (C, D) There was decreased scotopic and photopic electroretinography responses, consistent with the loss of photoreceptors.