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. 2014 Oct 14;53(50):13710–13714. doi: 10.1002/anie.201405485

Figure 1.

Figure 1

UOX-catalyzed reaction, mechanistic proposals, and alternative substrate. a) UOX degrades UA to 5-HIU. In solution, 5-HIU evolves spontaneously to a racemic mixture of allantoin, while in vivo it is rapidly degraded to (+)-allantoin by a separate enzyme system.[15] b) Peroxide-dependent[2d, 16] (path A) and peroxide-independent[5] (path B) mechanistic proposals. The shaded green area emphasizes the solvent network surrounding the five-membered ring. c) Chemical structure of MUA used in this study.