Figure 2.

Effects of IL-6 on carbachol-induced contraction of colon in rats. A. The contractile responses produced by carbachol on proximal colonic smooth muscle strips pretreated with IL-6 in control rats. Carbachol was applied at points marked by the arrow. B. Statistical data of tension induced by the carbachol on proximal colon pretreated with IL-6. C. The contractile responses produced by carbachol on distal colonic smooth muscle strips. Carbachol was applied at points marked by the arrows. D. Statistical data of tension induced by the carbachol on distal colon. Note that when distal colon is pretreated with IL-6, the carbachol-induced contraction increased. Control means the carbachol-induced contraction of colon treated with distilled water (50 μL) in Krebs solution. *P < 0.05 compared with Krebs solution. #P < 0.05 compared with control. n = 10.