Table 3.
Comparison of leukocyte count and neutrophils percentage in blood and bronchoalveolar lavage fluid among control group, paraquat group and rapamycin treatment group at 1, 3, 5, and 7 days after intraperitoneal injection ( x̅ ± s)
| Group | Time | n | Blood | BALF | ||
|---|---|---|---|---|---|---|
|
| ||||||
| Leukocyte count (× 109/L) | Neutrophils percentage (%) | leukocyte count (× 109/L) | Neutrophils percentage (%) | |||
| Control group | 1d | 12 | 2.91 ± 1.21 | 13.75 ± 5.52 | 0.18 ± 0.03 | 21.25 ± 2.35 |
| 3 d | 12 | 2.52 ± 1.18 | 15.69 ± 5.22 | 0.18 ± 0.02 | 21.05 ± 2.46 | |
| 5 d | 12 | 2.74 ± 1.43 | 16.94 ± 5.84 | 0.17 ± 0.01 | 21.53 ± 2.41 | |
| 7 d | 12 | 2.15 ± 1.13 | 15.50 ± 6.15 | 0.17 ± 0.04 | 20.89 ± 2.46 | |
| PQ group | 1 d | 12 | 7.95 ± 2.59a | 41.50 ± 10.20a | 0.32 ± 0.04a | 41.15 ± 9.68a |
| 3 d | 12 | 9.02 ± 4.00a | 51.78 ± 8.58a | 0.39 ± 0.12a | 42.37 ± 10.25a | |
| 5 d | 12 | 8.54 ± 3.10a | 55.42 ± 9.83a | 0.48 ± 0.05a | 44.70 ± 9.69a | |
| 7 d | 12 | 8.57 ± 2.97a | 57.67±9.68a | 0.40 ± 0.05a | 40.98 ± 4.76a | |
| RAPA treatment group | 1 d | 12 | 6.46 ± 2.58a | 40.62 ± 7.28a | 0.32 ± 0.06a | 40.45 ± 6.44a |
| 3 d | 12 | 6.10 ± 2.41ab | 36.40 ± 8.43ab | 0.32 ± 0.05a | 38.13 ± 6.78a | |
| 5 d | 12 | 5.65 ± 1.93ab | 35.10 ± 8.44ab | 0.29 ± 0.06ab | 34.10 ± 6.23ab | |
| 7 d | 10 | 4.98 ± 1.75ab | 34.15 ± 8.30ab | 0.29 ± 0.01ab | 32.49 ± 6.61ab | |
BALF, bronchoalveolar lavage fluid; Control group, Sprague-Dawley rats were intraperitoneally injected with 1.25 ml/kg saline solution; PQ group, Sprague-Dawley rats were intraperitoneally injected with 15 ml/kg 2% paraquat solution; RAPA treatment group, paraquat-poisoned Sprague-Dawley rats were immediately intraperitoneally injected with 1.25 ml/kg saline solution containing 4 mg/kg rapamycin; 1 d, 3 d, 5 d, 7 d, 1, 3, 5, and 7 days after intraperitoneal injection;
compared with control group, P < 0.05;
compared with PQ group, P < 0.05.