Figure 4.

Effect of miR-21 on CCA xenograft tumor growth in nude mice. A. The relative expression of mir-21 was explored in parental, pLVX-miR21-transfected and pLVX-NC-transfected QBC939 cells (QBC939-mir21), the expression level of mir21 in pLVX-miR21-transfected was significantly higher than that in other groups (F = 15.32, P < 0.01); B, C. pLVX-miR21-transfected cells and parental cells were subcutaneously injected into mouse to formate CCA xenograft models, Tumor volume was measured regularly; D. Tumor weight was measured on day 30 after mice sacrificed; *P < 0.05, **P < 0.01 versus the parental cell group.