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. 2015 May 1;8(5):5017–5025.

Figure 4.

Figure 4

miR-204 regulates apoptosis by targeting JAK2 in breast cancer cells. A. JAK2 and p-JAK2 expression levels in human breast cancer tissues and cell lines. *P<0.01 vs. NATs or MCF-10A group. B. miRNA levels of JAK2 in MCF-7 and MDA-MB-231 cells after treated with JAK2 for 48 h. *P<0.01 vs. Control group. C. JAK2 siRNA decreased the viability of breast cancer cells by MTT assay. The cell viability was significantly decreased after transfection with JAK2 siRNA for 48 h; n=6 *P<0.01 vs. Control group. D. Apoptosis of breast cancer cells after JAK2 siRNA treatment for 48 h by flow cytometry. Data are presented as means ± SEM of three separate experiments; *P<0.01 vs. Control group. E. p-STAT3, Bcl-2, survivin proteins were detected after transfection of miR-204 mimics.