Table 2.

Univariable and multivariable analysis of BC survival using Cox’s proportional hazards model

	Univariable analysis			Multivariable analysis
	HR	95% CI	P	HR	95% CI	P
OS
Age (<50 vs. ≥ 50 years)	0.289	0.049-1.701	0.170
Menopausal status (pre vs. post)	3.237	0.0558-18.774	0.190
TNM stage (I, II vs. III, IV)	3.222	0.391-5.817	0.031*	3.946	0.335-5.297	0.044*
ER status (negative versus positive)	1.886	0.623-5.712	0.261
PR status (negative versus positive)	0.395	0.134-1.166	0.093
Her-2 status (negative versus positive)	0.662	0.245-1.785	0.415
Lymph nodes metastasis (Yes vs. No)	4.963	1.364-18.058	0.015*	4.672	1.542-14.161	0.006**
Ki-67 status (negative versus positive)	7.725	0.952-62.705	0.039*	6.940	0.910-52.927	0.062
TMPRSS3 expression (High vs. Low)	10.163	1.221-84.586	0.032*	7.540	1.004-56.597	0.043*
DFS
Age (<50 vs. ≥ 50 years)	0.164	0.020-1.320	0.089
Menopausal status (pre vs. post)	3.510	0.466-26.461	0.223
TNM stage (I, II vs. III, IV)	1.227	0.364-4.138	0.742
ER status (negative vs. positive)	3.058	0.868-10.779	0.082
PR status (negative vs. positive)	0.295	0.086-1.009	0.052
Her-2 status (negative vs. positive)	0.682	0.227-2.049	0.495
Lymph nodes metastasis (Yes vs. No)	6.150	1.389-27.225	0.017*	7.500	2.146-26.218	0.002**
Ki-67 status (negative vs. positive)	7.678	0.919-64.165	0.060
TMPRSS3 expression (High vs. Low)	9.959	0.965-83.138	0.042*	7.370	0.974-55.762	0.049*

OS, overall survival; DFS, disease-free survival; HR, hazard ratio.

^* P<0.05;

^** P<0.01.