Table 2.

Information of 8 genotyped SNPs of gene VAMP8

SNP ID	Chromosome	Chromosome position	SNP locationa	Base change	Minor allele frequency			Genotyping rate (%)	P-value for HWEc	P-value for χ2	OR (95% CI)d
					Databaseb	Control	Case
rs3770098	2	85658878	intron	G/A	0.325	0.305	0.315	97.6%	0.31	0.536	0.95 (0.81-1.11)
rs7579147	2	85659165	intron	A/G	0.292	0.262	0.268	100%	0.88	0.711	0.97 (0.83-1.34)
rs3731828	2	85659777	synonymous	A/G	0.244	0.262	0.268	99.9%	0.92	0.711	0.97 (0.83-1.34)
rs1348818	2	85660593	intron	A/G	0.307	0.305	0.315	100%	0.16	0.536	0.95 (0.82-1.11)
rs13421434	2	85661121	intron	A/G	0.033	0.043	0.047	99.9%	0.44	0.555	0.90 (0.64-1.27)
rs1009	2	85662248	synonymous	A/G	0.305	0.305	0.316	100%	0.15	0.536	0.95 (0.82-1.11)
rs1058588	2	85662382	3’ UTR	A/G	0.305	0.305	0.316	100%	0.15	0.536	0.95 (0.82-1.11)
rs1010	2	85662493	3’ UTR	A/G	0.304	0.305	0.315	99.9%	0.17	0.562	0.96 (0.82-1.13)

Abbreviations: VAMP8, vesicle-associated membrane protein 8: SNP, single nucleotide polymorphism; HWE, Hardy-Weinberg equilibrium. The significant differences are indicated in bold.

^aSNP location in National Center for Biotechnology Information Genome build 37.3 (http://www.ncbi.nlm.nih.gov/projects/SNP/snp_ref.cgi?).

^bMinor allele frequency from dbSNP databases.

^cHWE P-value in control group.

^dAdjusted for gender, age, smoke and family history of cancer.