Table 3.
IL-17F allele and genotype in acute myeloid leukemia and control
| Polymorphism | AML (n, %) | Healthy control (n, %) | P value |
|---|---|---|---|
| IL-17F(A7488G)rs763780 | |||
| AA homozygotic type | 42 (67.7%) | 114 (91.2%) | > 0.05 |
| AG homozygous mutant | 15 (24.2%) | 11 (8.8%) | > 0.05 |
| GG heterozygous mutant | 5 (8.1%)b | 0 (0)b | < 0.01 |
| A single genotype | 57 (91.9%) | 125 (100%) | > 0.05 |
| G single mutant | 20 (32.3%)a | 11 (8.8%)a | < 0.05 |
IL-17F (A7488G) polymorphism variation was associated with AML;
a
RR = 4.75, P = 0.0009, pc = 0.0027;
b
RR = 23.01, P = 0.0036, pc = 0.0108.