Table 2.
SNP | Case (%) | Control (%) | Model | ||||
---|---|---|---|---|---|---|---|
|
|
||||||
N=348 | N=351 | OR (95 CI) | P-value | Model | OR (95% CI) | P-value | |
rs1799724 | |||||||
Genotype | |||||||
CC/CC | 215 (61.8) | 301 (85.8) | 1.00 (reference) | Dom | 3.72 (2.57-5.38) | 0.000 | |
TC/TC | 87 (25.0) | 44 (12.5) | 2.77 (1.85-4.14) | 0.000 | Rec | 8.76 (3.69-20.79) | 0.000 |
TT/TT | 46 (13.2) | 6 (1.7) | 10.73 (4.50-25.58) | 0.000 | Add | 3.00 (2.22-4.05) | <.0001 |
Alleles | |||||||
CC Alleles | 74.3 | 92.0 | 1.00 (reference) | 0.000 | |||
TT Alleles | 25.7 | 8.0 | 3.99 (2.90-5.51) | ||||
rs266085 | |||||||
Genotype | |||||||
CC/CC | 73 (21.0) | 66 (18.8) | 1.00 (reference) | Dom | 0.87 (0.60-1.27) | 0.472 | |
TC/TC | 141 (40.5) | 217 (61.8) | 1.70 (1.15-2.53) | 0.008 | Rec | 2.61 (1.85-3.67) | 0.000 |
TT/TT | 134 (38.5) | 68 (19.4) | 1.78 (1.14-2.77) | 0.010 | Add | 1.43 (1.15-1.77) | 0.001 |
Alleles | |||||||
CC Alleles | 41.2 | 49.7 | 1.00 (reference) | 0.000 | |||
TT Alleles | 58.8 | 50.3 | 1.41 (1.14-1.74) |
OR, odds ratios under a recessive model (OR=1 indicates no association between the gene and the disease; OR>1 indicates risk factor for the disease; OR<1 indicates protective factor against the disease); CI, confidence interval; Dom, dominant model; Rec, recessive model; Add, additive model.