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. 2015 May 1;8(5):5768–5774.

Table 2.

Comparison of rs1799724 and rs266085 genotype and allele frequencies in cervical cancer cases and controls

SNP Case (%) Control (%) Model
 

N=348 N=351 OR (95 CI) P-value Model OR (95% CI) P-value
rs1799724
    Genotype
        CC/CC 215 (61.8) 301 (85.8) 1.00 (reference) Dom 3.72 (2.57-5.38) 0.000
        TC/TC 87 (25.0) 44 (12.5) 2.77 (1.85-4.14) 0.000 Rec 8.76 (3.69-20.79) 0.000
        TT/TT 46 (13.2) 6 (1.7) 10.73 (4.50-25.58) 0.000 Add 3.00 (2.22-4.05) <.0001
    Alleles
        CC Alleles 74.3 92.0 1.00 (reference) 0.000
        TT Alleles 25.7 8.0 3.99 (2.90-5.51)
rs266085
    Genotype
        CC/CC 73 (21.0) 66 (18.8) 1.00 (reference) Dom 0.87 (0.60-1.27) 0.472
        TC/TC 141 (40.5) 217 (61.8) 1.70 (1.15-2.53) 0.008 Rec 2.61 (1.85-3.67) 0.000
        TT/TT 134 (38.5) 68 (19.4) 1.78 (1.14-2.77) 0.010 Add 1.43 (1.15-1.77) 0.001
    Alleles
        CC Alleles 41.2 49.7 1.00 (reference) 0.000
        TT Alleles 58.8 50.3 1.41 (1.14-1.74)

OR, odds ratios under a recessive model (OR=1 indicates no association between the gene and the disease; OR>1 indicates risk factor for the disease; OR<1 indicates protective factor against the disease); CI, confidence interval; Dom, dominant model; Rec, recessive model; Add, additive model.