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Schematic mechanism for the demethylation of methyl-lysine histone by JmjC catalysis. JmjC active site residues for FeII coordination are taken from a crystal structure of human KDM4A in complex with histone H3 peptide trimethylated at Lys 9 (PDB: 2OQ6[22]); NiII and N-oxalylglycine (NOG) are substitutes for FeII and 2OG, respectively.
