Table 3.
Best fit PI and estimated ha values from in vitro partitioning experiments
| Rotational speed | A/V a | M T /V a | Kap/(9.2 + Kap) | PI × 104 | (95% CI) | ha, full | (95% CI) | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Exp./Fig No. | Drug | Apparatus | pH | rpm | cm−1 | β | μg/ml | F o, inf | cm/s × 104 | μm | |||
| 3/3(a) | Ibuprofen | 1 | 1.5 | 77 | 0.42 | 1.58 × 10−4 | 16.7 | 1.00 | 1.00 | 23.71 | (22.16–25.41) | 32 | (29–34) |
| 4/3(b) | Ibuprofen | 1 | 4.3 | 77 | 0.42 | 2.84 × 10−4 | 16.7 | 1.00 | 1.00 | 30.06 | (29.45–30.68) | 25 | (24–25) |
| 5/3(c) | Ibuprofen | 1 | 4.4 | 77 | 0.42 | 3.17 × 10−4 | 16.7 | 1.00 | 1.00 | 37.52 | (30.30–47.73) | 20 | (16–25) |
| 6/3(d) | Ibuprofen | 1 | 6.3 | 77 | 0.42 | 1.28 × 10−2 | 16.7 | 0.99 | 0.89 | 30.81 | (28.79–33.03) | 22 | (20–23) |
| 7/4(a) | Ibuprofen | 2 | 5.0 | 75 | 0.30 | 9.87 × 10−4 | 25.0 | 1.00 | 0.99 | 19.08 | (18.13–20.10) | 39 | (37–41) |
| 8/4(b) | Ibuprofen | 2 | 6.8 | 75 | 0.30 | 5.00 × 10−2 | 50.0 | 0.95 | 0.73 | 28.73 | (24.64–33.73) | 19 | (16–22) |
| 9/4(c) | Ibuprofen | 2 | 6.8 | 75 | 0.30 | 5.0 × 10−2 | 25.0 | 0.95 | 0.73 | 26.85 | (26.09–27.63) | 20 | (20–21) |
| 10/4(d) | Ibuprofen | 2 | 6.8 | 40 | 0.30 | 5.00 × 10−2 | 25.0 | 0.95 | 0.73 | 10.92 | (10.69–11.17) | 50 | (49–51) |
| 11/4(e) | Ibuprofen | 2 | 7.5 | 75 | 0.30 | 1.44 × 10−1 | 25.0 | 0.87 | 0.49 | 23.01 | (20.07–26.59) | 16 | (14–18) |
| 12/4(f) | Ibuprofen | 2 | 7.5 | 40 | 0.30 | 1.44 × 10−1 | 25.0 | 0.87 | 0.49 | 9.03 | (8.38–9.70) | 40 | (38–43) |
| 13/4(g) | Ibuprofen | 3 | 4.5 | 50 | 0.32 | 3.58 × 10−4 | 16.0 | 1.00 | 1.00 | 28.72 | (25.45–32.65) | 26 | (23–29) |
| 14/5(a) | Piroxicam | 2 | 1.2 | 75 | 0.30 | 1.49 × 10−1 | 15.0 | 0.87 | 0.48 | 20.85 | (16.47–26.73) | 15 | (12–19) |
| 15/5(b) | Piroxicam | 2 | 1.2 | 75 | 0.30 | 1.49 × 10−1 | 20.0 | 0.87 | 0.48 | 17.06 | (16.77–17.36) | 19 | (18–19) |
| 16/5(c) | Piroxicam | 2 | 1.2 | 75 | 0.30 | 1.49 × 10−1 | 60.0 | 0.87 | 0.48 | 28.04 | (24.65–32.12) | 11 | (10–13) |
| 17/5(d) | Piroxicam | 2 | 7.5 | 40 | 0.30 | 2.53 | 20.0 | 0.28 | 0.05 | 1.64 | (1.48-1.80) | 21 | (19–23) |
| 18/5(e) | Piroxicam | 2 | 7.5 | 75 | 0.30 | 2.53 | 20.0 | 0.28 | 0.05 | 6.15 | (5.87–6.44) | 6 | (5–6) |
| 19/5(f) | Piroxicam | 2 | 7.5 | 75 | 0.30 | 2.53 | 60.0 | 0.28 | 0.05 | 1.78 | (1.75–1.81) | 19 | (19–20) |
| 20/5(g) | Nimesulide | 2 | 7.5 | 75 | 0.30 | 8.99 × 10−2 | 49.0 | 0.92 | 0.60 | 10.71 | (9.80–11.71) | 39 | (36–43) |
| 21/6(a) | Piroxicam | Grassi | 1.2 | Unknown | 0.23 | 0.357 | 15.2 | 0.74 | 0.48 | 265.4 | (257.7–273.5) | 12 | (12–12) |
| 22/6(b) | Piroxicam | Grassi | 7.5 | Unknown | 0.23 | 6.07 | 21.8 | 0.14 | 0.05 | 3.41 | (3.35–3.46) | 10 | (10–10) |
| 23/6(c) | Nimesulide | Grassi | 1.2 | Unknown | 0.23 | 3.59 × 10−2 | 8.5 | 0.97 | 0.90 | 22.98 | (22.71–23.25) | 27 | (27–28) |
| 24/6(d) | Nimesulide | Grassi | 7.5 | Unknown | 0.23 | 2.16 × 10−1 | 45.0 | 0.82 | 0.60 | 11.80 | (11.60–12.01) | 36 | (35–36) |