Table 2.
Univariate analysis of biological predictive factors and sinusoidal obstruction syndrome (SOS) by grade
| Preoperative biological variables | Group 1 | Group 2 | Group 3 | Group 4 | P-value |
|---|---|---|---|---|---|
| (SOS grade 0, n = 35) | (SOS grade 1, n = 49) | (SOS grade 2, n = 51) | (SOS grade 3, n = 16) | ||
| Mean (range) | Mean (range) | Mean (range) | Mean (range) | ||
| AST (normal: <50 U/l) | 25 (15–60) | 27 (15–92) | 30 (15–274) | 32 (21–100) | 0.130 |
| ALT (normal: <50 U/l) | 26 (14–78) | 25 (10–72) | 31 (11–277) | 30 (19–123) | 0.300 |
| AP (normal: 30–120 U/l) | 80 (29–218) | 99 (36–336) | 82 (49–672) | 93 (72–220) | 0.400 |
| GGT (normal: <50 U/l) | 45 (19–195) | 51 (10–327) | 59 (15–377) | 80 (19–377) | 0.033 |
| Direct bilirubin (normal: <0.3 mg/dl) | 0.1 (0–0.2) | 0.1 (0–0.4) | 0.1 (0–0.5) | 0.1 (0–0.3) | 0.018 |
| Platelet count (103) (normal: 150–300 × 103/ml) | 272 (171–393) | 222 (116–445) | 246 (62–484) | 197 (94–290) | 0.003 |
| Indocyanine green test (normal: <10%) | 4.8 (0.1–13.8) | 6.9 (0.4–16.7) | 7.7 (0.7–34) | 10.2 (3.9–34) | <0.001 |
| APRI score | 0.163 (0.080–0.556) | 0.198 (0.068–1.119) | 0.265 (0.087–4.529) | 0.325 (0.169–0.643) | <0.001 |
| Fib-4 score | 1.173 (0.580–2.394) | 1.504 (0.209–4.157) | 1.544 (0.330–6.395) | 1.658 (1.045–4.025) | <0.001 |
AST, aspartate aminotransferase
ALT, alanine aminotransferase
AP, alkaline phosphatase
GGT, γ-glutamyl-transferase
APRI, AST : platelet ratio index.