Table 3.
Endocrine and exocrine functions in the long-term after a a total pancreatectomy (TP) – Main published
| Authors | Period of time | N = | Median insulin units/d | Median hypo-glycaemia events | HbA1c | Median pancreatic lipase/d | Weight loss % of patients Nb of kg | Digestive symptoms |
|---|---|---|---|---|---|---|---|---|
| Crippa S et al.8 | 1996–2008 | 45 | 32 [18–52] | 2 [0–5] per week | 56% between 7 and 9 11% above 9% | 80 000 units [30 000–160 000] | 45% 5 kg [1–18] | Abdominal pain 22% Diarrhoea 13% |
| Muller et al.13 | 2001–2006 | 67 | 6.7% in benign disease 7.5% in malignant disease | 41% 13.5 kg [6–30] | Diarrhoea 41% Moderate to severe abdominal pain 15% | |||
| Billings et al.15 | 1985–2002 | 27 | 32 [2–66] | 7.4% (5.0–11.3] | 14 capsulesa [0–36] | 70% 12 kg [2–31] | ||
| Casadei et al.35 | 2006–2009 | 13 | 25 [20–52] | 4 [1–10] hypo + hyperglycemias per week | 8% [5.2–10.3] | 8 capsulesa [6–11] | 85% 15 kg [1–32] | |
| Present study | 1993–2010 | 25 | 16 [7–48] of long-acting insulin 21 [7–70] of rapid-acting insulin | 10 times [1–36] per month | 7.8 [6.3–10.3] 9 patients >8% | 150 000 units [75 000–450 000] | 60% 9 kg [2–14] | 2 [1–5] stools/day 28% with night stools |
a
Number of pancreatic enzyme units not specified.