Table 1.
Demographics and clinical information.
|
|
Schizophrenia patients (N = 31)
|
Healthy controls (N = 34)
|
|||
|---|---|---|---|---|---|
| Mean (N) | SD (%) | Mean (N) | SD (%) | p-Value | |
| Demographics | |||||
| Age (years) | 44.0 | 9.7 | 43.3 | 12.7 | 0.82 |
| Range | 23–61 | – | 20–64 | – | – |
| Education Level | 13.6 | 2.4 | 15.3 | 1.9 | 0.003** |
| Current Smoker | 11 | 35.5% | 7 | 20.6% | 0.27 |
| Race | 0.13 | ||||
| Caucasian | 6 | 19.4% | 17 | 50.0% | |
| African American | 8 | 25.8% | 7 | 20.6% | |
| Latino/Hispanic | 3 | 9.7% | 3 | 8.8% | |
| Asian American | 12 | 38.7% | 7 | 20.6% | |
| Other | 2 | 6.5% | 0 | 0.0% | |
| Clinical symptoms (N = 21) | |||||
| Positive | 16.1 | 4.2 | – | – | – |
| Negative | 15.1 | 5.4 | – | – | – |
| General | 31.4 | 9.6 | – | – | – |
| Medication Equivalents | |||||
| Cogentin | 0.4 | 0.6 | – | – | – |
| Chlorpromazine | 308 | 318 | – | – | – |
| Placebo | Oxytocin | Placebo | Oxytocin | ||
| Olfaction compounds | Median [IQR] | Median [IQR] | Median [IQR] | Median [IQR] | |
| Anise detection threshold | 1.1E – 4[9.1E – 6, 1.5E – 3] | 6.5E – 5[1.3E – 5, 4.3E – 4] | 4.3E – 4[2.5E – 5, 2.2E – 3] | 8.2E – 5[4.4E – 6, 1.5E – 3] | |
| Lyral detection threshold | 4.8E – 4[1.0E – 5, 3.8E – 2] | 5.3E – 5[1.1E – 6, 4.3E – 3] | 1.1E – 3[1.8E – 5, 6.7E – 2] | 2.2E – 4[1.0E – 5, 4.6E – 2] | |
| Placebo | Oxytocin–placebo | Placebo | Oxytocin–placebo | ||
| z-Score | Mean(SD) | Mean(SD) | Mean(SD) | Mean(SD) | |
| Anise | −0.34(0.12) | 0.28(0.94) | – | – | |
| Lyral | 0.09(1.09) | −0.33(0.83) | – | – | |
p ≤ 0.01.
p ≤ 0.05.
IQR = inter-quartile range.