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. Author manuscript; available in PMC: 2015 Jul 15.
Published in final edited form as: Mol Pharmacol. 2013 Dec 23;85(3):420–428. doi: 10.1124/mol.113.088526

Fig. 3.

Fig. 3

Inhibition of rh123 efflux was measured in the absence and presence of eight serial dilutions of GPV005. (A) Open diamonds, wild-type; filled circles, Y950F/Y953F; triangles, Y950F; squares, Y953F. IC50 values for GPV005 (B), GPV031 (C), and GPV366 (D) were determined by fitting hyperbolic concentration response curves to data points by nonlinear regression analysis and calculation of 50% occupancy values. Mean ± S.D. values were calculated from at least three independent experiments. *P < 0.05; **P < 0.01; ***P < 0.001, compared with wild-type P-gp.