Skip to main content
. Author manuscript; available in PMC: 2015 Jul 15.
Published in final edited form as: Mol Pharmacol. 2013 Dec 23;85(3):420–428. doi: 10.1124/mol.113.088526

Fig. 4.

Fig. 4

IC50 values for inhibition of rh123 efflux was measured for GPV005 (A), GPV031 (B), and GPV366 (C) by fitting hyperbolic concentration response curves to data points by nonlinear regression analysis and calculation of 50% occupancy values. The tyrosine mutants were generated in the Q132R mutation background. Mean ± S.D. values were calculated from at least three independent experiments. *P < 0.05; **P < 0.01; ***P < 0.001, compared with Q132R mutation.