Table 5. Concentrations (ng/mL) of tamoxifen metabolites (means (±SD), medians (in cursive) and ranges (in brackets)) detected in patients according to their UGT1A4, UGT2B7, UGT2B15 and UGT2B17 genotypes.

Genotype	4-OH-tamoxifen N-ß-D-glucuronide	4-OH-tamoxifen O-ß-D-glucuronide	Endoxifen ß-D-glucuronide	Tamoxifen	4-OH-tamoxifen	N-desmethyl-tamoxifen	Endoxifen	Tamoxifen-N-oxide
UGT1A4 Pro24Thr wt/wt (n = 113)	20.33 ± 11.44 17.87 [0.0–64.51]	4.85 ± 3.88 4.53 [0.0–18.97]	20.21 ± 15.28 16.84 [0.0–79.93]	200.11 ± 98.09 170.83 [77.10–576.23]	7.88 ± 7.50 6.11 [0.0–35.90]	448.40 ± 196.83 399.99 [35.96–1,210.09]	24.79 ± 19.72 19.38 [0.0–107.10]	49.64 ± 23.68 45.33 [15.69–142.97]
UGT1A4 Pro24Thr wt/24Thr (n = 16)	31.45 ± 34.27 21.49 [11.83–153.88]	7.77 ± 7.93 5.61 [0.0–34.42]	23.86 ± 18.70 18.25 [0.0–73.72]	214.97 ± 74.67 190.69 [115.35–371.37]	8.66 ± 7.04 6.53 [0.0–28.84]	443.04 ± 142.35 474.54 [228.81–638.82]	24.59 ± 20.78 16.39 [4.18–74.06]	55.29 ± 23.86 52.30 [17.43–106.35]
UGT1A4 Pro24Thr 24Thr/24Thr (n = 1)	16.93 ± 0.00 16.93	3.52 ± 0.00 3.52	10.80 ± 0.0 10.8	396.73 ± 0.00 396.73	8.01 ± 0.00 8.01	782.92 ± 0.00 782.92	30.30 ± 0.00 30.30	68.00 ± 0.00 68.00
P value	0.376	0.352	0.506	0.111	0.694	0.288	0.618	0.288
UGT1A4 Leu48Val wt/wt (n = 117)	21.51± 16.67 17.81 [0.00–153.88]	5.42 ± 4.66 4.64 [0.00–34.42]	20.78 ± 14.90 17.73 [0.00–73.72]	207.98 ± 97.88 184.21 [77.10–576.23]	8.06 ± 7.57 6.05 [0.00–35.90]	457.98 ± 198.55 418.46 [35.96–1,210.09]	25.55 ± 20.33 18.91 [0.00–107.10]	51.12 ± 23.42 48.81 [15.69–142.97]
UGT1A4 Leu48Val wt/48Val (n = 11)	21.07 ± 10.87 19.04 [6.13–41.62]	4.65 ± 3.91 4.58 [0.00–12.60]	23.48 ± 21.87 16.60 [0.00–79.93]	178.21 ± 72.97 153.75 [91.96–334.28]	8.06 ± 5.09 8.30 [0.00–16.29]	415.65 ± 121.96 448.61 [167.40–613.04]	19.26 ± 8.60 20.26 [5.13–31.21]	49.16 ± 26.64 42.72 [19.18–99.37]
UGT1A4 Leu48Val 48Val/48Val (n = 2)	18.13 ± 1.24 18.13 [17.25–19.01]	0.00 ± 0.00 0.00 [0.00–0.00]	3.75 ± 5.31 3.76 [0.00–7.51]	88.08 ± 0.00 88.08 [88.08–88.08]	0.00 ± 0.00 0.00 [0.00–0.00]	319.28 ± 0.00 319.28 [319.28–319.28]	4.46 ± 0.00 4.46 [4.46–4.46]	24.40 ± 0.00 24.40 [24.40–24.40]
P value	0.966	0.130	0.128	0.148	0.204	0.728	0.246	0.333
UGT2B7 His268Tyr wt/wt (n = 75)	21.45 ± 19.02 16.73 [0.00–153.88]	4.87 ± 3.61 4.37 [0.00–15.87]	20.35 ± 14.68 16.60 [0.00–79.93]	188.98 ± 92.07 167.01 [77.10–573.83]	6.70 ± 6.89 5.69 [0.00–35.90]	416.94 ± 189.52 372.61 [35.96–1,191.13]	23.61 ± 17.60 18.79 [0.00–95.87]	47.66 ± 23.95 41.84 [15.69–142.97]
UGT2B7 His268Tyr wt/268Tyr (n = 22)	22.63 ± 11.21 20.90 [4.81–45.21]	5.85 ± 5.20 4.40 [0.00–18.97]	22.45 ± 18.29 18.01 [0.00–71.00]	209.20 ± 82.63 187.36 [102.43–378.72]	7.02 ± 5.61 5.99 [0.00–26.98]	476.81 ± 172.86 472.41 [212.67–952.85]	19.06 ± 13.47 14.01 [5.01–51.89]	54.13 ± 25.03 52.30 [17.43–106.35]
UGT2B7 His268Tyr 268Tyr /268Tyr (n = 28)	20.30 ± 10.07 18.64 [3.88–37.76]	6.25 ± 6.37 4.71 [0.00–34.42]	21.59 ± 16.54 18.02 [0.00–73.72]	238.81 ± 116.07 203.66 [103.47–576.23]	11.37 ± 8.08 8.72 [0.00–30.96]	526.70 ± 211.73 487.68 [301.70–1,210.09]	33.22 ± 27.00 24.65 [4.57–107.10]	55.31 ± 22.98 52.30 [15.69–106.35]
P value	0.418	0.643	0.921	0.049	0.006	0.012	0.136	0.174
UGT2B15 Asp85Tyr wt/wt (n = 39)	20.83 ± 11.21 17.99 [4.81–62.07]	5.05 ± 4.01 4.25 [0.00–15.87]	22.36 ± 18.35 17.73 [0.00–79.93]	193.82 ± 97.03 167.01 [89.79–576.23]	7.86 ± 7.30 5.70 [0.00–30.96]	448.63 ± 206.96 364.81 [242.88–1,210.09]	26.01 ± 21.93 19.32 [0.00–95.87]	47.11 ± 23.69 40.10 [15.69–106.35]
UGT2B15 Asp85Tyr wt/85Tyr (n = 58)	23.47 ± 21.12 18.56 [0.00–153.88]	5.41 ± 5.22 4.91 [0.00–34.42]	20.67 ± 15.21 18.05 [0.00–73.72]	212.51 ± 105.11 184.50 [77.10–573.83]	8.53 ± 8.05 6.60 [0.00–35.90]	446.42 ± 193.80 398.77 [167.40–1,191.13]	25.06 ± 19.90 19.93 [4.46–107.10]	53.15 ± 24.44 50.56 [15.69–142.97]
UGT2B15 Asp85Tyr 85Tyr/85Tyr (n = 35)	19.58 ± 10.17 18.09 [0.00–47.54]	5.09 ± 4.17 4.64 [0.00–18.97]	18.46 ± 12.75 16.04 [0.00–49.99]	195.97 ± 78.13 169.73 [102.91–378.32]	6.89 ± 6.14 5.12 [0.00–26.98]	461.91 ± 175.10 455.07 [35.96–952.85]	22.62 ± 16.21 16.78 [4.03–53.75]	50.17 ± 21.69 45.33 [22.66–106.35]
P value	0.810	0.895	0.778	0.633	0.709	0.547	0.720	0.311
UGT2B15 Lys523Thr wt/wt (n = 37)	22.06 ± 24.58 15.92 [0.00–153.88]	3.91 ± 3.70 3.52 [0.00–18.97]	15.36 ± 11.66 14.80 [0.00–49.99]	198.25 ± 103.42 171.97 [77.10–576.23]	6.86 ± 8.24 4.68 [0.00–30.96]	448.88 ± 213.60 396.18 [196.74–1,210.09]	20.25 ± 17.12 16.39 [0.00–89.98]	49.28 ± 21.69 43.59 [20.53–106.35]
UGT2B15 Lys523Thr wt/523Thr (n = 68)	21.46 ± 12.40 18.62 [0.00–64.51]	5.28 ± 3.71 5.01 [0.00–15.83]	21.71 ± 16.29 18.31 [0.00–79.93]	200.38 ± 83.50 184.89 [88.08–515.07]	7.50 ± 5.58 6.36 [0.00–27.86]	458.19 ± 163.84 454.91 [212.67–968.42]	24.88 ± 17.96 21.05 [4.18–107.10]	49.52 ± 21.50 48.81 [15.69–111.58]
UGT2B15 Lys523Thr 523Thr /523Thr (n = 22)	20.15 ± 7.70 18.48 [9.62–37.68]	5.40 ± 4.16 4.48 [0.00–15.87]	19.87 ± 12.12 19.76 [0.00–51.78]	216.42 ± 116.89 176.45 [91.96–573.83]	10.07 ± 9.21 6.58 [0.00–35.90]	450.96 ± 248.30 409.42 [35.96–1,191.13]	28.72 ± 25.92 19.12 [5.40–95.87]	55.38 ± 32.17 45.33 [15.69–142.97]
P value	0.472	0.070	0.082	0.809	0.128	0.637	0.299	0.930
UGT2B17 wt/wt (n = 75)	22.58 ± 18.79 18.49 [0.00–153.88]	5.07 ± 4.78 4.64 [0.00–34.42]	19.28 ± 14.77 16.34 [0.00–73.72]	203.09 ± 95.32 184.50 [89.79–576.23]	7.34 ± 6.74 5.82 [0.00–30.96]	457.24 ± 179.79 421.86 [238.36–1,210.09]	24.69 ± 19.96 18.69 [0.00–107.10]	48.89 ± 20.72 44.46 [15.69–106.35]
UGT2B17 wt/del (n = 44)	18.75 ± 11.29 16.29 [0.00–64.51]	5.33 ± 4.34 4.16 [0.00–15.87]	22.36 ± 17.73 18.44 [0.00–79.93]	204.70 ± 106.03 175.91 [77.10–573.83]	9.61 ± 8.56 7.56 [0.00–35.90]	460.67 ± 223.90 389.90 [167.40–1,191.13]	27.02 ± 21.09 22.58 [4.03–95.87]	53.00 ± 28.85 45.33 [15.69–142.97]
UGT2B17 del/del (n = 12)	26.96 ± 12.38 25.11 [5.95–47.54]	5.53 ± 4.84 5.03 [0.00–18.97]	20.77 ± 12.51 19.77 [0.00–49.99]	203.34 ± 71.08 178.70 [130.69–375.04]	5.28 ± 5.09 4.86 [0.00–16.40]	410.68 ± 144.70 473.48 [35.96–545.30]	16.55 ± 8.88 15.98 [6.19–38.14]	51.40 ± 17.89 54.92 [22.66–78.45]
P value	0.042	0.934	0.646	0.846	0.141	0.928	0.325	0.796