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. 2015 Jul 9;2(4):e129. doi: 10.1212/NXI.0000000000000129

Figure 3. Predictive performance of wGRS.

Figure 3

The receiver operating characteristic curves are plotted considering 3 different models: weighted genetic risk score (wGRS) calculated with only with HLA-DRB1 alleles (green line), wGRS non-HLA (blue line), and wGRS calculated including all the 106 known genetic variants plus HLA allele (red line). The area under the curve (AUC) was calculated for the 3 different models, assessing the predictive capability in the entire multiple sclerosis (MS) cohort (A), in the subgroup of patients with sporadic MS (B), and in the subgroup of patients with familial MS (C). HLA = human leukocyte antigen; SNP = single nucleotide polymorphism.