Table 3. Resistance development under selective pressure of cefotaxime, meropenem, polymyxin B and C. vicina AMP complex.
| Selection agent | Transfers number | MIC, mg/L | КR * | P (ANOVA) | |
|---|---|---|---|---|---|
| Before selection | After selection | ||||
| E. coli 774.1 | |||||
| AMP complex | 25 | 250±0.0 | 330±80 | 1.32 | 0.374 |
| Cefotaxime | 25 | 0.17±0.04 | 2.0±0.0 | 11.8 | <0.001 |
| E. coli 774.1 | |||||
| AMP complex | 15 | 250±0.0 | 420±80.0 | 1.68 | 0.116 |
| Polymyxin B | 15 | 6.67±1.33 | 53.3±10.6 | 7.99 | 0.003 |
| E. coli 863.1 | |||||
| AMP complex | 15 | 420±80 | 500±0.0 | 1.19 | 0.374 |
| Meropenem | 15 | 0.125±0.0 | 8.0±0.0 | 64 | <0.001 |
| K. pneumoniae 104.2 | |||||
| AMP complex | 25 | 830±170 | 500±0.0 | 0.60 | 0.116 |
| Meropenem | 25 | 0.125±0.0 | 16.0±0.0 | 128 | <0.001 |
| A. baumannii 882.2 | |||||
| AMP complex | 35 | 420±0.08 | 500±0.0 | 1.19 | 0.374 |
| Polymyxin B | 35 | 2.7±0.3 | 8.0±0.0 | 2.96 | 0.007 |
*KR−ratio of MIC after selection to MIC before selection.