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. 2015 Jul 15;10(7):e0129866. doi: 10.1371/journal.pone.0129866

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© 2015 Cipriani et al

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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Fig 3 — GPBAR1^+/+ and-^/- mice were treated for 10 days with ANIT or with the combination of ANIT plus BAR502. At the end of the treatments mice were subjected to intradermal injection of DCA. (A-B) Survival of GPBAR1^+/+ and-^/- mice in response to ANIT administration. (C) Effect of ANIT on spontaneous scratching and scratching induced by DCA. Scratching tests were performed at day 5. Results are expressed as the number of scratching events during 60 minutes of observation. Results are the mean ± SE of 4–8 mice per group. *p<0.05 versus GPBAR1^+/+ mice subjected to intradermal injection of DCA. #p<0.05 versus GPBAR1^-/- mice subjected to intradermal injection of DCA.