Table 5. The genotype frequencies of the eight SNPs.
| Variables | Controls (n = 186) | NSCLC (n = 159) | non-cardiac GC (n = 167) | EC (n = 110) | |||
|---|---|---|---|---|---|---|---|
| n (%) | n (%) | p | n (%) | p | n (%) | p | |
| GWAS rs465498 | 0.382* | 0.050 * | 0.155* | ||||
| AA | 123 (66.1) | 113 (71.1) | ref. | 123 (73.7) | ref. | 82 (74.5) | ref. |
| GA | 54 (29.0) | 39 (24.5) | 0.330 | 42 (25.1) | 0.299 | 24 (21.8) | 0.152 |
| GG | 9 (4.8) | 7 (4.4) | 0.749 | 2 (1.2) | 0.039 | 4 (3.6) | 0.509 |
| GWAS rs17728461 | 0.269* | 0.661* | 0.152* | ||||
| CC | 98 (52.7) | 104 (65.4) | ref. | 92 (55.1) | ref. | 66 (60.0) | ref. |
| CG | 79 (42.5) | 39 (24.5) | 0.001 | 66 (39.5) | 0.598 | 40 (36.4) | 0.255 |
| GG | 9 (4.8) | 16 (10.1) | 0.237 | 8 (4.8) | 0.914 | 3 (2.7) | 0.296 |
| GWAS rs4488809 | 0.933* | 0.788* | 0.195* | ||||
| CC | 41 (22.0) | 38 (23.9) | ref. | 37 (22.2) | ref. | 34 (30.9) | ref. |
| CT | 97 (52.2) | 88 (55.3) | 0.603 | 90 (53.9) | 0.679 | 48 (43.6) | 0.764 |
| TT | 48 (25.8) | 33 (20.8) | 0.959 | 40 (24.0) | 0.798 | 26 (23.6) | 0.204 |
| GWAS rs753955 | 0.705* | 0.001 * | 0.244* | ||||
| AA | 88 (47.3) | 75 (47.2) | ref. | 59 (35.3) | ref. | 49 (44.5) | ref. |
| GA | 85 (45.7) | 69 (43.4) | 0.829 | 74 (44.3) | 0.259 | 45 (40.9) | 0.844 |
| GG | 13 (7.0) | 15 (9.4) | 0.459 | 34 (20.4) | 0.000 | 15 (13.6) | 0.078 |
| GWAS rs13361707 | 0.626* | 0.005 * | 0.786* | ||||
| TT | 41 (22.0) | 46 (28.9) | ref. | 62 (37.1) | ref. | 23 (20.9) | ref. |
| CT | 91 (48.9) | 71 (44.7) | 0.731 | 68 (40.7) | 0.745 | 51 (46.4) | 0.759 |
| CC | 54 (29.0) | 41 (25.8) | 0.591 | 37 (22.2) | 0.007 | 33 (30.0) | 0.802 |
| GWAS rs9841504 | 0.953* | 0.390* | 0.612* | ||||
| CC | 142 (76.3) | 119 (74.8) | ref. | 133 (79.6) | ref. | 85 (77.3) | ref. |
| CG | 40 (21.5) | 35 (22.0) | 0.869 | 32 (19.2) | 0.553 | 23 (20.9) | 0.892 |
| GG | 4 (2.2) | 3 (1.9) | 0.886 | 2 (1.2) | 0.466 | 1 (0.9) | 0.424 |
| GWAS rs2274223 | 0.143* | 0.213* | 0.793* | ||||
| AA | 106 (57.0) | 106 (66.7) | ref. | 93 (55.7) | ref. | 65 (59.1) | ref. |
| GA | 73 (39.2) | 46 (28.9) | 0.047 | 56 (33.5) | 0.555 | 39 (35.5) | 0.586 |
| GG | 7 (3.8) | 7 (4.4) | 1.000 | 18 (10.8) | 0.017 | 5 (4.5) | 0.801 |
| GWAS rs13042395 | 0.070* | 0.016 * | 0.792* | ||||
| CC | 112 (60.2) | 76 (43.1) | ref. | 72 (43.1) | ref. | 64 (58.2) | ref. |
| CT | 59 (31.7) | 70 (44.0) | 0.015 | 83 (49.7) | 0.001 | 40 (36.4) | 0.507 |
| TT | 15 (8.1) | 13 (8.2) | 0.547 | 12 (7.2) | 0.598 | 5 (4.5) | 0.313 |
NSCLC, non-small cell lung cancer; non-cardia GC, non-cardia gastric cancer; EC, esophageal cancer.
* p values for Cochran-Armitage trend test, α = 0.05.
p values for prtitions of chi-square test, α = 0.0125.